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• W2361683112 abstract "Objective: To investigate the effect of conditionally replicating oncolytic adenoviruses with promoter of MK (midkine) (Ad-MK) alone or in combination with MMC (mitomycin) on proliferation of human bladder carcinoma EJ cells and its possible mechanism. Methods: The expression levels of MK mRNA in EJ cells and adenovirus E1a mRNA in Ad-MK-infected EJ cells were detected by RT-PCR (reverse transcription-PCR). The effect of Ad-MK alone or in combination with MMC on survival rate of EJ cells was detected by MTT method, and the morphological change of EJ cells was observed under an optical microscope. Virus yield of Ad-MK was determined by TCID50 (50% tissue culture infectious dose) in the presence of MMC. A murine xenograft model of human bladder transitional cell cancer was established. The effect of Ad-MK alone or in combination with MMC on the growth of the murine xenografts was examined. Results: The MK mRNA was expressd in the EJ cells. The expression of E1a mRNA could be detectable in the Ad-MK-infected EJ cells. Ad-MK inhibited the proliferation of the cells in a dose- and time-dependent manner. There was a synergistic effect of Ad-MK in combination with MMC. The EJ cells infected with Ad-MK and treated with MMC produced a larger amount of viruses than the EJ cells infected with Ad-MK and not treated with MMC did in vitro and in vivo (P < 0.05). The growth of murine xenografts of Ad-MK-infected and MMC-treated EJ cells was inhibited as compared with that of the murine xenografts of Ad-MK-infected EJ cells (P < 0.01). Conclusion: Ad-MK can selectively replicate and inhibit the proliferation of EJ cells in a dose- and time-dependent manner. There maybe a synergistic effect of Ad-MK in combination with MMC. The potential growth inhibition effects of combined treatment proves to be superior to either virus or MMC treatment alone, and MMC can augment virus replication. DOI:10.3781/j.issn.1000-7431.2013.07.001" @default.
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• W2361683112 date "2013-07-25" @default.
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• W2361683112 title "The inhibitory effect of conditionally replicating adenovirus combined with mitomycin on the proliferation of bladder cancer cells" @default.
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