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- W2361686039 abstract "OBJECTIVE To establish HPLC-MS method for determination of nateglinide in human plasma.METHODS The extraction solvent was acetonitrile.Liquid-liquid extraction was used to treat with human plasma.The HPLC separation of nateglinide and diazepam(internal standard)was performed on an Agilent Zorbax SB-C18(100 mm×2.1 mm,5μm)column with acetonitrile-5mmol·L-1 ammonium acetate water solution(55∶45,v/v)as the mobile phase and a flow rate of 0.3 mL·min-1.A Waters ZQ 2000 HPLC-MS system with an atmospheric pressure chemical ionization(APCI)source was used as the detector and was operated in a positive ion mode.Selected ion monitoring(SIM)was performed and the m/z of ions selected for quantification were 318.43(nateglinide)and m/z 285.30(internal standard,diazepam).RESULTS Calibration curve for nateglinide was linear over the range of 0.05～15 mg·L-1.The lower limit of quantitation was 10μg·L-1.The method recoveries were 90.1%-95.8%.The inter and intra day precisions were less than 4.9% and 6.1%.CONCLUSION The method was proved to be sensitive,accurate and convenient.It can be applied to study the pharmacokinetics of nateglinide in human plasma." @default.
- W2361686039 created "2016-06-24" @default.
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- W2361686039 date "2010-01-01" @default.
- W2361686039 modified "2023-09-25" @default.
- W2361686039 title "Determination of Nateglinide in Human Plasma by HPLC-MS" @default.
- W2361686039 hasPublicationYear "2010" @default.
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