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- W2361689277 abstract "Objective To primarily evaluate the specific immune response level induced in mice by combined immunization with inactivated enterovirus 71(EV71) vaccine and inactivated hepatitis A virus(HAV) vaccine as well as the interaction of EV71 and HAV antigens.Methods Combined vaccine was prepared by formulation of inactivated HAV and inactivated EV71 vaccines at various dosage ratios,with which ICR mice were immunized and determined for serum anti-HAV titer by ELISA,for serum neutralizing antibody titer against EV71 by virus fixation-serum dilution method,for percentage of lymphocyte subsets CD4+/CD8+ in spleen by flow cytometry,and for IL-4 and IFNγ levels secreted by lymphocytes in spleen by ELISPOT.Results All the positive rates of neutralizing antibody against EV71 in sera of mice in various groups reached 100% 28 d after primary immunization and 7 d after booster immunization,while the neutralizing antibody titers were dose-dependent.Protective HAV antibody was induced in sera of mice 28 d after primary immunization,which increased after booster immunization.The antibody levels induced by combined vaccine showed no significant difference with those by the corresponding monovalent vaccine(P 0.05),and no interaction between EV71 and HAV was found.The percentages of CD8+ cells in spleens of mice in various groups were significantly higher 28 d after primary immunization(P 0.001),while was significantly lower 7 d after booster immunization,than those of CD4+ cells(P 0.001).Neither whole HAV nor EV71 polypeptide stimulated the secretion of cytokines by splenocytes of mice in various groups 28 d after primary immunization,however,7 d after booster immunization,the IL-4 levels secreted by splenocytes of mice in various groups were significantly higher than those of IFNγ(P 0.05).Conclusion Combined immunization with HAV and EV71 vaccines at certain dosages induced high humoral immune response and relatively low cellular immune response.However,no interference or synergism was observed between the two vaccine antigens." @default.
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- W2361689277 date "2012-01-01" @default.
- W2361689277 modified "2023-09-27" @default.
- W2361689277 title "A primary evaluation on effect of combined immunization with inactivated enterovirus 71 vaccine and inactivated hepatitis A virus vaccine" @default.
- W2361689277 hasPublicationYear "2012" @default.
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