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- W2361694920 abstract "Objective To explore the mechanism of nasal tolerance by nasal administration of myelin basic protein (MBP) in guinea pigs for inducing immune tolerance and preventing experimental autoimmune encephalomyelitis (EAE). Methods Guinea pigs were, to begin with, given MBP through the nasal route to induce the development of peripheral immune tolerance, and then immunized with specific antigen MBP plus complete Freund's adjuvant (CFA). The clinical symptoms of guinea pigs were investigated, and the erythrocyte rosette test, and lymphocyte blastogenesis test, the MBP specific skin delayed type hypersensitivity (DTH) response and the levels of interlukin 4 (IL 4) and interferon γ (IFN γ) were also detected, and the pathological changes were examined as well. Results Nasal tolerance could effectively prevent the development of EAE clinically. The erythrocyte rosette test, lymphocyte blastogenesis test and MBP specific skin DTH response were also obviously suppressed. An evident increasing of IL 4 level while a decreasing of IFN γ level was found after the culture of peripheral blood lymphocytes. Conclusion This experimental study suggested that the nasal administration of small amount of antigens had been a highly efficient approach in inducing clinical relevant tolerance, and it might provide a simple and promising way for the protection and treatment of a number of many autoimmune diseases, including EAE. It was suspected that the suppression of EAE in this experimental study might be associated with down regulation of the Th1 response or secretion of proinflammatory cytokines, i.e., IFN γ and with up regulation of the Th2 response or secretion of anti inflammatory cytokines, i.e., IL 4." @default.
- W2361694920 created "2016-06-24" @default.
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- W2361694920 date "1999-01-01" @default.
- W2361694920 modified "2023-09-24" @default.
- W2361694920 title "A study of nasal administration of myelin basic protein of prevents experimental autoimmune encephalomyelitis in guinea pigs" @default.
- W2361694920 hasPublicationYear "1999" @default.
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