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• W2361732292 abstract "Aim To investigate the effects of the combinations of Astragaloside Ⅳ( the effective component of Astragalus) and Ginsenoside Rg1, Ginsenoside Rb1,Notoginsenoside R1( the effective components of Panax notoginseng) on oxidative stress and nuclear factor-erythroid 2 related factor 2( Nrf2) / heme oxygenase( HO)-1 pathway after cerebral ischemic-reperfusion in mice. Methods C57BL /6 mice were randomly grouped,treated for 3 days,and 1 h after the last administration,cerebral ischemia-reperfusion injury was established by bilateral common carotid artery ligation for 20 min followed by reperfusion for 24 h. Malondialdehyde( MDA),nitric oxide( NO),superoxide dismutase( SOD),glutathione( GSH),HO-1mRNA expression in tissues and the expressions of Nrf2 in cytoplasm and nucleus,HO-1 in whole cell were determined. Results 1. After cerebral ischemic reperfusion for 24 h,the contents of MDA,NO were increased,SOD activity and GSH level were decreased as well. Astragaloside Ⅳ significantly inhibited the increase of MDA,NO,and Ginsenoside Rg1 obviously reduced NO content. Astragaloside Ⅳ + Ginsenoside Rg1,Astragaloside Ⅳ + Ginsenoside Rb1 and Astragaloside Ⅳ + Notoginsenoside R1 obviously all reduced the contents of MDA and NO,and the effects of Astragaloside Ⅳ + Ginsenoside Rb1 and Astragaloside Ⅳ + Notoginsenoside R1 were better than those of Ginsenoside Rb1,Notoginsenoside R1 alone. 2. After cerebral ischemic reperfusion for 24 h,Nrf2 protein content was increased in cytoplasm and nucleus,nuclear translocation rate was raised, at the same time, HO-1mRNA and HO-1 protein expression in brain tissues were significantly up-regulated. In different degree, Nrf2 protein content was significantly decreased in cytoplasm and significantly increased in nucleus,nucleartranslocation rate was raised in treatment groups,and the effects of Astragaloside Ⅳ + Ginsenoside Rg1,Astragaloside Ⅳ + Ginsenoside Rb1 and Astragaloside Ⅳ + Notoginsenoside R1 were better than those of the active components alone. Astragaloside Ⅳ,Ginsenoside Rg1,Astragaloside Ⅳ + Ginsenoside Rg1,Astragaloside Ⅳ + Ginsenoside Rb1 and Astragaloside Ⅳ + Notoginsenoside R1 could obviously increase HO-1 mRNA and HO-1 protein,and the effects of Astragaloside Ⅳ + Ginsenoside Rg1,Astragaloside Ⅳ + Ginsenoside Rb1 and Astragaloside Ⅳ + Notoginsenoside R1 were better than those of the active components alone. Furthermore,the elevatory effects on Nrf2 in nucleus,nuclear translocation rate of Astragaloside Ⅳ + Ginsenoside Rg1 were stronger than those of Astragaloside Ⅳ + Ginsenoside Rb1,the elevatory effects on HO-1 mRNA and HO-1 protein were stronger than those of Astragaloside Ⅳ + Ginsenoside Rb1 and Astragaloside Ⅳ + Notoginsenoside R1. Conclusions Astragaloside Ⅳ respectively combined with three active components of Panax notoginseng strengthens the antagonism effects on oxidative stress injury after cerebral ischemic-reperfusion. The underlying mechanism might be associated with activating Nrf2 / HO-1 signal transduction pathway,promoting the synthesis and nuclear translocation of Nrf2,then advancing the expression of antioxidant gene in the downstream such as HO-1. The effects were more obvious in Astragaloside Ⅳ + Ginsenoside Rg1." @default.
• W2361732292 created "2016-06-24" @default.
• W2361732292 creator A5077099876 @default.
• W2361732292 date "2013-01-01" @default.
• W2361732292 modified "2023-09-24" @default.
• W2361732292 title "Effects of combinations of astragaloside IV and three active components in notoginseng on oxidative stress and Nrf2 /HO-1 pathway after cerebral ischemic-reperfusion in mice" @default.
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