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- W2361742317 abstract "Objective: To observe the antithrombotic effect and safety of warfarin in the anticoagulant therapy for patients with nonvalvular atrial fibrillation. Methods: 117 patients with nonvalvular atrial fibrillation under the anticoagulant therapy of warfarin were allocated into 2 groups: 67 patients in group(international normalized ratio 1.6～2.4) ; 50 patients in group(INR 2.5～3.5). the incidence rates of complications with thromboembolism and adverse effects with hemorrhage etc were observed. Results: The annual rate of thromboembolism in group(INR 1.6～2.4) is 0.75%, in group(INR 2.5～3.5) is 0, there is no significant difference between 2 groups(P0.05). 94% adverse effects in 2 groups are hemorrhage, the annual rate of hemorrhage in group(1.6～2.4) is 6.9%, in group(2.5～3.5) is 16.2%, it differ significantly (P0.005), but all the hemorrhage cases are not serious. Other adverse effects includes skin rash and digestive symptoms. Conclusions: When INR between 1.6 to 3.5, the warfarin treatment can obviously cut down the thromboembolism rate in patients with nonvalvular artial fibrillation and the treatment is safe. There is some risk for thromboembolism when INR between 1.6 to 2.4, and some risk for hemorrhage when INR between 2.5 to 3.5." @default.
- W2361742317 created "2016-06-24" @default.
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- W2361742317 date "2004-01-01" @default.
- W2361742317 modified "2023-09-25" @default.
- W2361742317 title "An observation of anticoagulant effect of warfarin in the therapy for patients with nonvalvular atrial fibrillation" @default.
- W2361742317 hasPublicationYear "2004" @default.
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