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- W2361742979 abstract "Objective:To develop a rapid and simple HPLC method for the simultaneous determination of aciclovir, ganciclovir and penciclovir in plasma.Methods:After being purified by solid phase extraction cartridges,samples were achieved and separated by a C_(18)column with a mobile phase of 0.015 mol·L~(-1)phosphate buffer(adjusted to pH 3.14 with dilute phosphoric acid)-CH_3OH(90:10)at a flow-rate of 1.0 mL·min~(-1),temperature set at 40℃,and measured by fluorescence detection using an excitation wavelength of 270 nm and an emission wave- length of 373 nm.Guanine was chosen as the internal standard.Results:The drug-free plasma did not interfere with the drugs and internal standard,all components were eluted in 10 minutes and separated each other.The linear equations were Y=0.024947+0.084400 C(r=0.9992)for gancielovir,Y=0.016342+0.078968 C(r=0.9999) for aciclovir and Y=0.038859+0.44034C(r=0.9998)for penciclovir,respectively.The linearity ranged from 0.1 to 50.0μg·mL~(-1)for both ganciclovir and aciclovir and from 0.04 to 20.0μg·mL~(-1)for penciclovir,respective- ly.At a signal-to-noise ratio of 3:1,the detection limit was 0.05μg·mL~(-1)for both ganciclovir and aeiclovir and 0.01μg·mL~(-1)for penciclovir,respectively.The extraction recoveries of these drugs were all higher than 70% and method recoveries varied from 90% to 110%.The precisions(RSD)of within-day and between-day were all less than 6%.Conclution:This methond is simple,rapid,accurate and sensitive.It can be used to determine the concentrations of ganciclovir,aciclovir and penciclovir in plasma simultaneously and rapidly,and can be applied to the clinical pharmaceutical research in vivo." @default.
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- W2361742979 date "2006-01-01" @default.
- W2361742979 modified "2023-09-25" @default.
- W2361742979 title "Simultaneous and rapid determination of aciclovir,ganciclovir and penciclovir in plasma with solid- phase extraction and HPLC" @default.
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