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- W2361752689 abstract "Objective:To observe the effect of Zhi Zhu Decoction on substance P(SP) and vasoactive intestine peptide(VIP) expression in colon of mice with spleen-deficiency constipation.Methods:The mice models of spleen-deficiency constipation were induced by splenasthenic diarrhea,irregular diet and fluid-consuming constipation.Then the model mice were divided into three groups,treated with Zhi Zhu Decoction,Bianmi Tong Oral Liquid,distilled water,respectively.The expression of SP and VIP in the colon was tested by immunohistochemical staining.Results:The expression of SP and VIP was lower in the model group(treated with distilled water) than that in the normal group(P 0.01).After treatment,the expression levels of SP and VIP were close to the normal level in the highand middledose Zhi Zhu Decoction groups.Conclusion:Target-regulation mechanisms of Zhi Zhu Decoction on the gastrointestinal motility of spleen-deficiency constipation mice may be related to the regulation of SP and VIP levels." @default.
- W2361752689 created "2016-06-24" @default.
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- W2361752689 date "2011-01-01" @default.
- W2361752689 modified "2023-09-26" @default.
- W2361752689 title "Effect of Zhi Zhu Decoction on Substance P and Vasoactive Intestine Peptide Expression in the Colon of Spleen-Deficiency Constipation Mice" @default.
- W2361752689 hasPublicationYear "2011" @default.
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