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- W2361764297 abstract "Objective: To prepare docetaxel(DTX)-loaded Solutol HS15 /Pluronic F127 mixed micelles(SF-DTX),optimize its formulation and evaluate the properties including shape,particle size,envelop rate,in vitro release characteristic and cytotoxicity of the SF-DTX prepared under the optimized conditions.Methods: The SF-DTX mixed micelles was prepared by thin-film hydration method.Its formulation was optimized via the combination of Doehlert Matrix Design method and Desirability Function method.The morphology of SF-DTX was observed under transmission electron microscope(TEM),and the particle size was measured by laser granulometry.The in vitro release behavior of SF-DTX was determined by the dialysis method.In addition,the in vitro cytotoxicity of SF-DTX was assessed by using human lung adenocarcinoma cell line A549.Results: The SF-DTX prepared based on the optimized formulation showed spherical shape,with a particle size of(22.74 ± 0.43) nm and envelop rate of more than 90%.The 24 h-accumulated release ratio in vitro of the preparation was(62.3 ± 2.54) %.The stability of SFDTX after multi-fold dilution was higher than that of single micellar system.The cytotoxicity of SF-DTX on A549 cells was significantly stronger than that of free DTX and blank mixed micelles.Conclusion: Solutol HS15 / Pluronic F127 mixed micelles exhibits several characteristics,including small particle size,high stability,the capability of improving the solubility of the loaded-drug and sustained release effect.It is a promising delivery system for anticancer drugs." @default.
- W2361764297 created "2016-06-24" @default.
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- W2361764297 date "2013-01-01" @default.
- W2361764297 modified "2023-09-24" @default.
- W2361764297 title "Preparation and In Vitro Evaluation of Docetaxel-loaded Solutol HS 15/Pluronic F127 Mixed Micelles" @default.
- W2361764297 hasPublicationYear "2013" @default.
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