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- W2361768013 abstract "Objective To study the effect of epidural block on vecuronium-induced neuromuscular block by observing the time-course of the recovery of thumb and toe under pure general anesthesia(GA)or combined general and epidural anesthesia(cGEA).Methods Forty patients of American Society of Anesthesiologists(ASA)Ⅰ-Ⅱ,who were scheduled for abdominal total hysterectomy,were assigned to Group GA and Group American Society of Anesthesio logiscs(cGEA).Patients in Group cGEA underwent epidural puncture at L1-L2;and 10 min after intubation,local anesthetics were administered.General anesthesia was induced routinely.After calibration and single twitch stimulation height(T1/Tc)was stabilized at 100%,0.1 mg/kg vecuronium was administered to facilitate tracheal intubation.Ulnar nerve and tibial nerve were stimulated separately;train-of-four ratio(TOFR)and T1/Tc were measured with the train-of-four(TOF)-Watch SX acceleromyograph simultaneously.Repeated vecuronium was given when TOFR at the thumb recovered to 0.25.The onset time and the time need to return of T1,T2,T3,T4,and the times of TOFR=0.25,0.90 were recorded.T1/Tc was recorded every 5 min.When patients were transferred to post-anesthesia care unit,Bromage scores were evaluated.Results The onset time of Group GA was significantly longer at the thumb and the toe than that of Group cGEA after first and last repeated administration(P0.01).There were no significant differences in the time period needed to return of T2,T3,T4 and duration of action(the times of TOFR recovering to 0.25)between the two groups either at the thumb or at the toe.The times to return of T2,T3,T4 and the times of TOFR recovering to 0.25 after first repeated administration were longer at the thumb in Group cGEA than in Group GA(P0.05,0.01),with no difference found at the toe.After the last administration,the times to return of T1,T2,T3,T4,and the times of TOFR recovering to 0.25 and 0.90 were longer at the thumb in Group cGEA than in Group GA(P0.05,0.01),with no significant difference found at the toe between the two muscle groups.Conclusions Epidural anesthesia can accelerate the onset of vecuronium,and delay the recovery of its neuromuscular function,but epidural anesthesia cannot change the relationship between the thumb and toe." @default.
- W2361768013 created "2016-06-24" @default.
- W2361768013 creator A5051316009 @default.
- W2361768013 date "2010-01-01" @default.
- W2361768013 modified "2023-09-25" @default.
- W2361768013 title "Effect of epidural block on vecuronium-induced neuromuscular block" @default.
- W2361768013 hasPublicationYear "2010" @default.
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