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- W2361789869 abstract "Objective:To investigate effects of rosuvastatin on plaque and the content of serum pregnancy-associated plasma protein-a (PAPP-A) of rabbit model with atherosclerosis.Methods:18 New Zealand rabbits were randomly divided into Normal control (Normal, n=6) group and Atherosclerosis (AS,n=6) group and rosuvastatin treated (RSV, n=6) group.we measured the level of serum TC, TG, LDL-C, HDL-C and PAPP-A.EEMA, LA, PA and LAS% were measured with intravascular ultrasound (IVUS) after treatment.Results:Before treatment, the level of serum TC, TG, LDL-C and PAPP-A in AS and RSV group were significantly highter than those in Normal groups (P0.01), while the level of serum HDL-C in AS and RSV group were significantly lower than those in Normal groups (P0.01).After treatment, compared with rabbits in AS group, the content of serum TC, TG, LDL-C and PAPP-A were significantly lower in RSV group (P0.01), while the content of serum HDL-C were significantly higher in RSV group (P0.01).Compared with before treatment, the content of serum TC, TG, LDL-C and PAPP-A were significantly lower in RSV group (P0.01) while the content of serum HLDL-C were higher in RSV group (P0.01) after treatment.The result of LAS% measured with IVUS showed the value of LAS% were significantly lower in RSV group (30.87%±5.27%) than those in AS group (37.42%±6.12%) (P0.01) after treatment.Conclusion:Rosuvastatin can improve blood fat, inhibit formation of plaque and downregulate the level of serum PAPP-A." @default.
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- W2361789869 date "2010-01-01" @default.
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- W2361789869 title "Effects of rosuvastatin on plaque and serum PAPP-A of rabbit model with atherosclerosis." @default.
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