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- W2361796614 abstract "OBJECTIVE: To study the effects of continuous intravenous infusional (CIV) tegafur or 5-fluorouracil (5-FU) combined with oxaliplatin in the treatment of advanced gastric cancer. METHODS: Sisty-seven advanced gastric cancer patients were treated with regimen A or regimen B. Regimen A: tegafur 800 mg/m2, CIV (24 h),d1-d5; LV 200 mg/m2, iv(2 h),d1-d5; L-OHP 135 mg/m2, iv(2 h),d1. Regimen B: 5-FU 750 mg/m2,CIV (24 h),d1-d5; the suage of LV and Loup is sawe as the regimen A. Regimen A and B were repeated every 21 days. RESULTS: There were 9 CR, 34 PR cases in the 67 patients. Response rate (RR) was 64.0%. TTP and MST were 7.2 months and 11.3 months respectively. The RRs of regimen A and B were 68.8% and 60.0% respectively. The difference did not reach the level of statistical significance (χ2=0.557,P=0.456). The RRs of naive-chemotherapy and pre-chemotherapy patients were 73.7% and 60.4% respectively. For pre-chemotherapy patients, the RRs of regimen A and regimen B were 69.6% and 60.4% respectively. The difference did not reach the level of statistical significance (χ2=1.545,P=0.214). The adverse effects of the two regimens were mild. CONCLUSIONS: The ragiment of continuous intravenous infusional (CIV) tegafur or 5-fluorouracil (5-FU) combined with oxaliplatin for advanced gastric cancer is safe and effective." @default.
- W2361796614 created "2016-06-24" @default.
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- W2361796614 date "2007-01-01" @default.
- W2361796614 modified "2023-09-23" @default.
- W2361796614 title "Comparative study of continuous intravenous infusional tegafur or 5-fluorouracil combined with oxaliplatin in the treatment of advanced gastric cancer" @default.
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