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- W2361797631 abstract "【Objective】This study sought to determine the mechanism and treatment of hypercoagulative state in patients after catheter closure of atrial septal defect (ASD). 【Methods】We studied 82 patients undergoing catheter closure of ASD. The levels of antithrombin-III (AT-III), fibrinogen (Fib), D-dimer (D-D) and tissue-type plasminogen activator (t-PA) were measured before ASD closure, at the 30th minute and on the third day after ASD closure. The effect of heparin on the levels of AT-III, Fib, D-D and t-PA were determined. 【Results】At 30th minute after ASD closure there were significantly lower AT-III activity and higher levels of Fib, D-D and t-PA than those before ASD closure (P 0.01). AT-III activity and t-PA levels decreased significantly on the third day after ASD closure compared with those before ASD closure and at 30th minute after ASD (P 0.01). On the third day after ASD closure there were significantly lower levels of Fib and D-D than those at 30th minute after ASD closure (P 0.01) but higher levels of Fib and D-D than those before ASD closure (P 0.01). There was positive relationship between levels of Fib, D-D and t-PA and duration of catheter performance in vessel and heart (r was 0.464, 0.758 and 0.251 respectively. P 0.01,P 0.01,P 0.05). On the third day after ASD closure there were higher AT-III activity and lower levels of Fib and t-PA in patients treated with low-molecular-weight heparin for three days than those in patients treated with low-molecular-weight heparin for only one day (P 0.01). 【Conclusions】There was a hypercoagulative state in patients for decreasing activation of anticoagulation and increasing activation of coagulation after catheter closure of ASD. The hypercoagulative state in patients after catheter closure of ASD could be relieved by treating with low-molecular-weight heparin." @default.
- W2361797631 created "2016-06-24" @default.
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- W2361797631 date "2009-01-01" @default.
- W2361797631 modified "2023-09-24" @default.
- W2361797631 title "Study of hypercoagulative state in patients after catheter closure of atrial septal defect" @default.
- W2361797631 hasPublicationYear "2009" @default.
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