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- W2361803223 abstract "Objective:To detect the blood glucose levels in 97 patients with colorectal cancer before and during 5-fluorouracil(5-FU)-based chemotherapy and elucidate the association between 5-FU chemotherapy and the initiation of diabetes mellitus(DM) in colorectal cancer patients.Methods:This study retrospectively analyzed the fasting blood glucose levels before and during 5-FU-based chemotherapy in 97 patients with colorectal cancer.Results:Three patients with DM,3 patients with impaired fasting glucose(IFG) and 1 patient with impaired glucose tolerance(IGT) were excluded from this study.A total of 90 non-diabetic patients were analyzed,of whom 5(5/90,5.56%) patients developed DM,16(16/90,17.78%) patients had IFG,and 1(1/90,1.11%) patient developed IGT during the chemotherapy period.The average fasting blood glucose levels of the 5 diabetic patients was markedly increased during chemotherapy compared with that before chemotherapy [(12.20±6.23)mmol/L vs(4.95±0.31)mmol/L,P0.01].The median cumulative dose of 5-FU was 7 500 mg/m2 till the occurrence of DM and median therapy period was 2 cycles till the appearance of hyperglycemia.Four patients had received glucocorticoids therapy.The median cumulative dose of dexamethasone was 25 mg till the secondary DM occurred.One patient with the secondary DM died of ketoacidosis.Twelve out of the 16 patients was recovered from the secondary IFG at 2 to 7 months after termination of chemotherapy,and the other 4 patients did not recover from the secondary IFG.None of 16 IFG patients developed DM.Conclusion:The 5-FU-based chemotherapy induced secondary DM of colorectal patients and caused severe ketoacidosis.Some patients had transient IFG during 5-FU chemotherapy." @default.
- W2361803223 created "2016-06-24" @default.
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- W2361803223 date "2010-01-01" @default.
- W2361803223 modified "2023-09-23" @default.
- W2361803223 title "Influence of 5-fluorouracil-based combined chemotherapy on glucose metabolism in patients with colorectal cancer" @default.
- W2361803223 hasPublicationYear "2010" @default.
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