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- W2361806904 abstract "Objective To explore the difference of GSTμ gene deficiency among the groups of workers exposed to benzene. Methods Polymerase chain reaction (PCR) method was used to investigate the rates of GSTμ gene deletion in workers exposed to benzene. Results The rate of GSTμ gene deletion in patients with severe benzene intoxication, moderate benzene intoxication, mild intoxication and benzene exposure, was 69.84%, 56.00%, 53.75% and 51.79%, which was significantly higher than that of the controls, 46.88%, P0.05. The rates of GSTM1 gene deletion in the groups were increased with the severity of poisoning. An analysis of correlation was conducted that its coefficient of correlation was statistically significant difference (r=1.92, P0.05). GSTμ gene deletion may be an important host hereditary marker for susceptibility to leukemia exposed to benzene. The rate of GSTμ gene deletion in leukemia patients exposed to benzene was 73.53%, which was significantly higher than of the controls (44.44%), P0.01. Conclusion GSTμ gene deletion may be an important host hereditary marker for susceptibility to intoxication exposed to benzene." @default.
- W2361806904 created "2016-06-24" @default.
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- W2361806904 date "2002-01-01" @default.
- W2361806904 modified "2023-09-23" @default.
- W2361806904 title "ANALYSIS ON GLUTATHIONE S-TRANSFERASEμ POLYMORPHISM IN THE POPULATION EXPOSED TO BENZENE" @default.
- W2361806904 hasPublicationYear "2002" @default.
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