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- W2361811144 abstract "OBJECTIVE To investigate whether the drug has notable impact on the nervous system, respiratory system and the cardiovascular system for its safe use.METHODS Xingnaojing injection with low[0.5 ml·(100 g)~-1 ],middle[1.5 ml·(100 g)~-1 ] and high[3.0 ml·(100 g)~-1 ] doses were given to the rats iv to observe the changes on the nervous system, and low[0.9 ml·(100 g)~-1 ],middle[1.8 ml·(100 g)~-1 ] and high[3.6 ml·(100 g)~-1 ] doses was given to the anesthetized SD rats in iv to see the effect on the respiratory system and cardiovascular system.RESULTS Compared with pre-drug and NS group, changes of the nervous , respiratory system and blood pressure had no statistics difference after giver giving Xingnaojing ingection iv with low, middle and high doses,either in the ECG signals (the interval of PR,ST,the wave of P,T)at low and middle doses. But at high dose, 20 times of the normal dose on person, obvious extension of the interval of QRS in electro-cardiogram occured, which indicated a latent restricion on the conduction of heart.CONCLUSION It is safe when use Xingnaojing injection in normal dose, but more attention should be paid to its potential restriction on the conduction of heart at with high dose." @default.
- W2361811144 created "2016-06-24" @default.
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- W2361811144 date "2005-01-01" @default.
- W2361811144 modified "2023-09-24" @default.
- W2361811144 title "Research on general pharmacology of Xingnaojing injection" @default.
- W2361811144 hasPublicationYear "2005" @default.
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