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- W2361818063 abstract "OBJECTIVE:To study the distribution of sliver in plasma and tissues of burnt rats with Nano-silver cream.METHODS:Deep Ⅱ degree scald model of 5% total body surface area(5 cm×5 cm)of rats was established and randomly divided into Nano-silver cream group,Flamazine cream group and base control group with 8 rats in each group.They were applied cream to injured infection site coating with 0.1-0.2 cm,once a day for consecutive 30 d.Rats were sacrificed 24 h after drug withdrawal.The contents of sliver in plasma,heart,liver,spleen and kidney were determined by ICP-MS.The condition of determination was as follows:radio-frequency power 1 250 W,impulse voltage 1 200 V,flow velocity of atomizing gas 0.80 L/min,flow velocity of plasma gas 15 L/min.RESULTS:The linear range of sliver was 0.01-10.00 μg/ml(r=0.999 9)with recoveries of(93.2±3.3)%(112.5±1.0)%(RSD3.5%,n=8).Compared with base control group,the contents of sliver in plasma,heart,liver,spleen and kidney increased significantly in Flamazine cream group(P0.05 or P0.01),while the contents of sliver in only spleen increased significantly in Nano-silver cream group(P0.05).CONCLUSIONS:Results show that no significant accumulations of Nano-silver cream in plasma and tissue except spleen of rats." @default.
- W2361818063 created "2016-06-24" @default.
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- W2361818063 date "2013-01-01" @default.
- W2361818063 modified "2023-09-26" @default.
- W2361818063 title "Distribution of Sliver in Plasma and Tissues of Burnt Rats with Nano-silver Cream" @default.
- W2361818063 hasPublicationYear "2013" @default.
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