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- W2361818325 abstract "Objective To explore the effect of berberine on the function of endothelial vessels,IL-6 and TNF-a in newly diagnosed patients with type 2 diabetes mellitus.Methods 60 patients newly diagnosed with type 2 diabetes patients were selected as treatment group,half of them treated by insulin combined with berberine,others only treated by insulin.Glucose level,vascular false hemophilia factor(VWF),blood clots regulatory proteins(TM) and endothelial cell protein C receptor(EPCR) level in all patients were detected before and after the treatment,comparing with the control group(n=30).Results Before treatment,VWF,TM,EPCR,IL-6 and TNF-α of all the patients were significantly higher than those of control group(P0.05),while the fasting blood glucose,postprandial blood glucose,HbA1C,VWF,TM,EPCR,IL-6 and TNF-α in patients treated by insulin combined with berberine were not different from those of patients only treated by insulin.After treatment,fasting blood glucose,postprandial blood glucose,HbA1C,VWF,TM,EPCR,IL-6 and TNF-α of all the patients obviously lower than those of before treatment(P0.05),and the fasting blood glucose,postprandial blood glucose and HbA1C in patients treated by insulin combined with berberine also had no difference from those of patients only treated by insulin.However,after treatment with berberine and insulin,VWF,EPCR and IL-6 were lower than those of patients with only insulin(P0.05).Conclusion Berberine can inhibit inflammatory factor to protect the endothelial function of vessels in type 2 diabetes." @default.
- W2361818325 created "2016-06-24" @default.
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- W2361818325 date "2011-01-01" @default.
- W2361818325 modified "2023-09-26" @default.
- W2361818325 title "Research on the Effect of Berberine on the Function of Endothelial Vessels,IL-6 and TNF-a in Newly Diagnosed Patients with Type 2 Diabetes Mellitus" @default.
- W2361818325 hasPublicationYear "2011" @default.
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