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- W2361820937 abstract "AIM To study the systemic effects of cholangioghaphy in different conditions of bile duct in animal experiment. METHODS Fifty one rabbits were divided into six groups randomly in order to make different pathophysiological conditions of the bile duct. Normal control group ( n =5), cholangiography group ( n =5); obstructed group ( n =7), cholangiography+obstructed group ( n =7), obstructed+cholangiography+reobstructed ( n =13); obstructed+cholangiography+disobstructed group ( n =14). Cholangiography was performed in each group. Samples were collected after the pressure of bile duct was measured in all groups except for one group 24 hours after cholangiography. Oxygen free radical, endotoxin, gastral motolin, hepatic cAMP, β endophin in brain were also detected. RESULTS There was no obvious change in various parameters in cholangiography group compared with the control group. Oxygen free radical ( P 0 01), endotoxin ( P 0 01), gastral motolin ( P 0 01), β endophin ( P 0 05), hepatic cAMP ( P 0 05) became significantly higher in the obstructed+cholangiography+reobstructed group than the control group. Timely depression of bile duct pressure showed that the oxygen free radical level declined obviously ( P 0 05) and endotoxin showed a falling tendency. CONCLUSION Cholangiography in physiologic state has no adverse effect on the organism, and under the obstructive condition of bile duct, the pathologic changes were mainly related to the obstruction itself. Timely and effective depression of bile duct pressure could improve this injury process." @default.
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- W2361820937 date "1997-01-01" @default.
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- W2361820937 title "Experimental study on the systemic effects of cholangiography in different conditions of bile duct" @default.
- W2361820937 hasPublicationYear "1997" @default.
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