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- W2361822187 abstract "Objective To investigate the effect of endothelial-monocyte activating polypeptideⅡ(EMAP-Ⅱ)on the permeability of blood-tumor barrier(BTB)in brain glioma rats and determine the optimal condition of EMAP-Ⅱ. Methods Immunohistochemistry was used to measure the distribution of endogenous EMAP-Ⅱin the normal brain tissues and the tumor tissues.The permeability of BTB after different concentration of exogenous EMAP-Ⅱinfusion was measured by Evans blue(EB)assay.Results In glioma rats'model,immunohistochemistry analysis showed that endogenous EMAP-Ⅱmainly expressed in the microvessels and neuron in normal brain tissues,while in tumor microvessels and tumor cells in tumor tissues.The effect of different concentration of exogenous EMAP-Ⅱon BTB permeability for EB extravasation increased,but no normal brain was involved.The permeability of BTB reached a peak at 1h after administration of exogenous EMAP-Ⅱ,then decreased gradually and restored to the level before administration of exogenous EMAP-Ⅱ.40 ng/kg tissues is the optimal concentration of exogenous EMAP-Ⅱ.Conclusion EMAP-Ⅱcould increase the permeability of BTB selectively in a dose-dependent manner." @default.
- W2361822187 created "2016-06-24" @default.
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- W2361822187 date "2008-01-01" @default.
- W2361822187 modified "2023-09-25" @default.
- W2361822187 title "Dose-Response Relation of EMAP-IISelectively Increased the Permeability of Blood-Tumor Barrier in Glioma Rats" @default.
- W2361822187 hasPublicationYear "2008" @default.
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