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- W2361824265 abstract "[Objective] To detect Annexin A1 expression in primary gastric cancer and lymph node metastasis,and explore the association of Annexin A1 expression with clinicopathological features and the prognosis in gastric cancer.[Methods] Tissue microarray blocks,containing 70 pairs of primary gastric cancers and matched metastatic lymph nodes,and 30 cases of adjacent non-tumor gastric tissues were constructed.Expression of ANXA1 in these specimens was analyzed using immunohistochemistry.[Result] ANXA1 was negatively expressed in non-tumor gastric tissues.The positive expression of ANXA1 was detected in 4/70(5.7%)of primary gastric cancers and 17/70(24.3%)of metastatic lymph nodes,respectively.The difference was statistically significant(P 0.05).Expression of ANXA1 in metastatic lymph nodes was correlated with advanced TNM stages(P 0.05).In Kaplan-Meier analysis,the survival time was shorter in the patients with metastatic expression of ANXA1 than in those with negative ANXA1 expression(P 0.05).In logistic regression,metastatic expression of ANXA1 is a risk factor associated with patient early death.[Conclusion] ANXA1 expression was significantly related with gastric cancer distant metastasis and patient early death." @default.
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- W2361824265 date "2011-03-20" @default.
- W2361824265 modified "2023-09-27" @default.
- W2361824265 title "Relationship between Expression of Annexin A1 and Prognosis in Gastric Cancer" @default.
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