Matches in SemOpenAlex for { <https://semopenalex.org/work/W2361828298> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2361828298 abstract "Objective To investigate the therapeutic effects of sinomenine on the activity of brain nuclear factor-κB (NF-κB) rat in experimental autoimmune encephalomyelitis (EAE). Methods EAE rats were induced by immunization of female Wistar rats with brain and spinal cord homogenate followed by treatment with or without sinomine. The severity of EAE rats was evaluated by clinical scores and histological examination. The activity of brain NF-κB and the plasma cortisol were determined by ELISA kits. Plasma prolactin was assessed by the RIA kit. Results The brain NF-κB binding activity was increased significantly in EAE rats. The treatment of sinomenine reduced the clinical scores of EAE significantly, decreased the number of inflammatory foci in the central nervous system, and inhibited the activation of brain NF-κB in EAE rats. Besides, the level of plasma cortisol was increased and the level of plasma prolactin was decreased after the treatment of sinomenine. Conclusion Inhibiting brain NF-κB binding activity could be a mechanism of sinomenine protecting of rats from EAE, and the inhibition of NF-κB is related to the alteration of cortisol and prolactin in vivo." @default.
- W2361828298 created "2016-06-24" @default.
- W2361828298 creator A5059940147 @default.
- W2361828298 date "2005-01-01" @default.
- W2361828298 modified "2023-09-25" @default.
- W2361828298 title "Sinomenine inhibits brain nuclear factor-κB activity in rat experimental autoimmune encephalomyelitis" @default.
- W2361828298 hasPublicationYear "2005" @default.
- W2361828298 type Work @default.
- W2361828298 sameAs 2361828298 @default.
- W2361828298 citedByCount "0" @default.
- W2361828298 crossrefType "journal-article" @default.
- W2361828298 hasAuthorship W2361828298A5059940147 @default.
- W2361828298 hasConcept C118552586 @default.
- W2361828298 hasConcept C126322002 @default.
- W2361828298 hasConcept C134018914 @default.
- W2361828298 hasConcept C150903083 @default.
- W2361828298 hasConcept C185592680 @default.
- W2361828298 hasConcept C207001950 @default.
- W2361828298 hasConcept C2777662524 @default.
- W2361828298 hasConcept C2777899865 @default.
- W2361828298 hasConcept C2778402981 @default.
- W2361828298 hasConcept C2778486448 @default.
- W2361828298 hasConcept C2780775167 @default.
- W2361828298 hasConcept C529278444 @default.
- W2361828298 hasConcept C71924100 @default.
- W2361828298 hasConcept C86803240 @default.
- W2361828298 hasConcept C98274493 @default.
- W2361828298 hasConceptScore W2361828298C118552586 @default.
- W2361828298 hasConceptScore W2361828298C126322002 @default.
- W2361828298 hasConceptScore W2361828298C134018914 @default.
- W2361828298 hasConceptScore W2361828298C150903083 @default.
- W2361828298 hasConceptScore W2361828298C185592680 @default.
- W2361828298 hasConceptScore W2361828298C207001950 @default.
- W2361828298 hasConceptScore W2361828298C2777662524 @default.
- W2361828298 hasConceptScore W2361828298C2777899865 @default.
- W2361828298 hasConceptScore W2361828298C2778402981 @default.
- W2361828298 hasConceptScore W2361828298C2778486448 @default.
- W2361828298 hasConceptScore W2361828298C2780775167 @default.
- W2361828298 hasConceptScore W2361828298C529278444 @default.
- W2361828298 hasConceptScore W2361828298C71924100 @default.
- W2361828298 hasConceptScore W2361828298C86803240 @default.
- W2361828298 hasConceptScore W2361828298C98274493 @default.
- W2361828298 hasLocation W23618282981 @default.
- W2361828298 hasOpenAccess W2361828298 @default.
- W2361828298 hasPrimaryLocation W23618282981 @default.
- W2361828298 hasRelatedWork W1525934216 @default.
- W2361828298 hasRelatedWork W2039280620 @default.
- W2361828298 hasRelatedWork W2354990924 @default.
- W2361828298 hasRelatedWork W2355354739 @default.
- W2361828298 hasRelatedWork W2356877805 @default.
- W2361828298 hasRelatedWork W2357802691 @default.
- W2361828298 hasRelatedWork W2357835281 @default.
- W2361828298 hasRelatedWork W2361739453 @default.
- W2361828298 hasRelatedWork W2367214911 @default.
- W2361828298 hasRelatedWork W2368493926 @default.
- W2361828298 hasRelatedWork W2375930687 @default.
- W2361828298 hasRelatedWork W2378180336 @default.
- W2361828298 hasRelatedWork W2382859194 @default.
- W2361828298 hasRelatedWork W2389190391 @default.
- W2361828298 hasRelatedWork W2413708382 @default.
- W2361828298 hasRelatedWork W2893062655 @default.
- W2361828298 hasRelatedWork W2972999804 @default.
- W2361828298 hasRelatedWork W2978737291 @default.
- W2361828298 hasRelatedWork W3028987695 @default.
- W2361828298 hasRelatedWork W3161053816 @default.
- W2361828298 isParatext "false" @default.
- W2361828298 isRetracted "false" @default.
- W2361828298 magId "2361828298" @default.
- W2361828298 workType "article" @default.