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- W2361867537 abstract "To explore the effect of different culture conditions on endothelial cells of diabetic cell model( VEC)and smooth muscle cells( VSMC) proliferation,apoptosis; to test metabolites in the diabetic model of VEC and VSMC,to provide experimental evidence for the selection of metabolic biomarkers precursor in the early diagnosis of diabetic cardiovascular complications.By simulating the diabetes blood environment,establishing diabetes VEC and VSMC cell model separately,using MTT method and Hoechst 33258 fluorescent staining method to observe the morphology and growth of cells under different culture conditions,the lactate dehydrogenase( LDH),reactive oxygen species( ROS) activity will be tested.Result showed that high sugar culture induced the proliferation of VEC and VSMC in a short term,VEC reached its maximum growth rate within 24 h while VSMC reached its maximum growth rate in 48 h.However,high sugar led to the cell death and morphology changes in long range interactions significantly.After culturing 30 mM for 48 h,the LDH,ROS in VEC cells grew significantly,the apoptosis rate can be noticed easily.As to the flipped ROS and LDH in reseratrol methylene amine( RMI) increased,the suffered damage in simulated environment diabetes decreased.Tipped cultured metabolic gas point in VSMC VEC cells was collected to use as mass spectrometry data within 48 h.ROS,LDH in cell model of diabetes increased significantly.The induced cell death by activation suggested severe diabetes blood glucose,blood ketone serious disorders,acidosis significantly of patients.Metabolic precursors can be presumed as pyruvate,LDH,etc.Acetone and CO2 in the breathing gas are substance candidate for early diagnosis of cardiovascular complications of diabetes." @default.
- W2361867537 created "2016-06-24" @default.
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- W2361867537 date "2014-01-01" @default.
- W2361867537 modified "2023-09-27" @default.
- W2361867537 title "Application research of vascular metabolites in the early diagnosis of diabetic cardiovascular complications" @default.
- W2361867537 hasPublicationYear "2014" @default.
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