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- W2361882913 abstract "Purpose:To study the effects of killing drug resistant bladder cancer cells by the use of transferred bak gene and adriamycin and illustrate its mechanisms.Methods:Bak gene was transfected into drug resistant bladder cancer cells by liposome. The expressions of bak and bcl 2 were detected by in situ hybridization. The survival rate was worked out by MTT after adriamycin was added in and IC 50 and resistant factor were calculated. The accumulation of adriamycin in the cells were examined by spectrofluorometry.Results:The expression of bak mRNA was positive in EJ/bak cells. The survival rate of EJ/bak cells was significantly decreased compared with the cells in which adriamycin was added (P 0.05 ). The accumulation of adriamycin in the cells did not increase significantly.Conclusions:The use of transferred bak gene and adriamycin could kill drug resisant bladder cancer cells more efficiently. But bak gene did not operate through helping adriamycin into cells." @default.
- W2361882913 created "2016-06-24" @default.
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- W2361882913 date "2001-01-01" @default.
- W2361882913 modified "2023-09-25" @default.
- W2361882913 title "Bak gene cooperating with adriamycin to kill drug-resistant bladder cancer cells" @default.
- W2361882913 hasPublicationYear "2001" @default.
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