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- W2361885705 abstract "Objective To investigate the effects of hypoxia on the expression of cysteine-rich protein 61(Cyr61/CCN1) in murine osteoblasts. Methods Murine osteoblasts were cultured under oxygen of lower concentration or treated with desferrioxamine,and Real-time PCR and Western blotting were employed to detect the expression of HIF-1α,Cyr61/CCN1 and vascular endothelial growth factor in osteoblasts at different time points.HIF-1α gene or VHL gene were knocked out in murine osteoblasts,and the expression of Cyr61/CCN1 in murine osteoblasts was detected. Results HIF-1α pathway was activated in murine osteoblasts under the condition of hypoxia,and the expression of Cyr61/CCN1 in osteoblasts was significantly increased(P0.05 or P0.01).The expression of Cyr61/CCN1 was significantly decreased in murine osteoblasts with HIF-1α gene knockout,and that was significantly increased in osteoblasts with VHL gene knockout(P0.05 or P0.01). Conclusion The expression of Cyr61/CCN1 in murine osteoblasts may be up-regulated by hypoxia through activation of HIF-1α pathway." @default.
- W2361885705 created "2016-06-24" @default.
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- W2361885705 date "2009-01-01" @default.
- W2361885705 modified "2023-09-26" @default.
- W2361885705 title "Effects of hypoxia on expression of Cyr61/CCN1 in murine osteoblasts" @default.
- W2361885705 hasPublicationYear "2009" @default.
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