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- W2361888023 abstract "Objective To investigate the effects of NGF(Nerve Growth Factor) pretreatment on expression VEGF and KDR/flk-1 of acute myocardial infaction in rats.Methods 60 male adult Wistar rats were randomly classified into three groups: the control(n=20),non-NGF(n=20) and NGF(n=20) groups.The NGF group was injected NGF(0.5 μg/kg) via caudal vena.Then we performed left anterior descending coronary artery(LAD) ligation by means of electrotome.In this study we observe the morphologic changes of myocardial pathology in each group;To measure the expression of vascular endothelial growth factor(VEGF) and KDR/flk1 we use immunohistology and RT-PCR.Results Infarct areas of rats had statistically significant differences among groups(F=12.13,P0.01),but the damage in NGF group(25.41±9.06)% was significantly less than non-NGF group(40.08±11.38)%,P0.01.Differences of VEGF,KDR/flk-1 mRNA expression had statistics significance between groups(F=18.23,14.10,all P0.01).Compared to non-NGF group VEGF(32.34±8.10)、KDR/flk-1(31.09±7.88) were higher in the NGF group VEGF(45.41±11.54)、KDR/flk-1(47.40±7.83),all P0.01.A positive correlation was showed between VEGF mRNA and KDR/flk-1 mRNA(r=0.691,P0.01).Conclusion The NGF pretreaement can enhance the new vessels density in cardiac muscle,through the rise of expression of VEGF and KDR/flk-1,and lessen the myocardial damage induced by AMI in rats." @default.
- W2361888023 created "2016-06-24" @default.
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- W2361888023 date "2011-01-01" @default.
- W2361888023 modified "2023-09-26" @default.
- W2361888023 title "Influence of Nerve Growth Factor Pretreatment on expression VEGF and KDR/flk-1 in AMI rats" @default.
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