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- W2361888465 abstract "Objective To investigate the protective effect of CIB1-siRNA pretreatment on the brain against ischemia-reperfusion in rats.Methods 120 male SD rats weighing 290～310 g were randomly divided into 3 groups:sham operation group(S group,n=40);middle cerebral artery occlusion group(MCAO)(A group,n=40)and CIB1-siRNA +MCAO group(B group,n=40).The middle cerebral arteries of rats in A group and B group were blocked,MCAO was maintained for 1 h and the nylon thread was withdrawn to allow reperfusion.In B group,CIB1-siRNA solution(2.5 mg/kg)was given i.v.immediately before MCAO,at 24 h and 16 h after MCAO.In S group,the internal carotid artery was exposed but no MCAO was performed,and PBS solution was given instead of CIB1-siRNA solution.The animals in all groups were killed at 1,5,11,23 and 47 h after reperfusion(n=8 at each time point).Brains were immediately removed and sliced.The infarct size was estimated by using Kontron IBAS 2.5 image auto-analysis system.The Caspase-3 mRNA expression was measured by RT-PCR.Results The infarct size of rats in A group and B group reached the peak at 23 h after reperfusion,and was significantly bigger than that in S group at 47 h after reperfusion(P0.01).The infarct size of rats in B group was significantly bigger than that in A group(P0.01).The expression of Caspase-3 protein in A group and B group reached the peak at 23 h after reperfusion.The expression levels of Caspase-3 protein in B group was higher than that in A group.Conclusion CIB1-siRNA pretreatment can aggravate the brain I/R injury to some extent." @default.
- W2361888465 created "2016-06-24" @default.
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- W2361888465 date "2010-01-01" @default.
- W2361888465 modified "2023-09-25" @default.
- W2361888465 title "Effect of CIB1 Silence on the Expression of Caspase-3 in Brain Tissues of Rats with Brain Ischemia-reperfuslon Injury" @default.
- W2361888465 hasPublicationYear "2010" @default.
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