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- W2361892106 abstract "Objective To explore the effect of naloxone on alcoholic fatty liver (AFL) in rats and its possible mechanism.Methods 48 Wistar male rats were divided randomly into four groups:Model group,naloxone low dose group,naloxone high dose group and normal control group.By the end of the fourth week,all rats were weighted,narcosised,sacrificed,and got the whole liver.Level of β-endorphin (β-EP),aspartate aminotransferase (AST),alanine aminotransferase (ALT) and glutathione s-transferasc (GST) in plasma were measured.Liver sample were analyzed for histopathology with microscope.Results Rat models of AFL were established successfully.Contrast with normal control group,the level of β-EP,AST,ALT,GST in plasma increased in model group and decreased in treatment group markedly (P0.01).Classic hepatocyte fatty degeneration were observed in model group.Conclusion Long-term alcohol and excessive drinking can increase the level of β-endorphin (β-EP) in plasma; naloxone can decrease β-EP level in plasma and prevent the formation of AFL." @default.
- W2361892106 created "2016-06-24" @default.
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- W2361892106 date "2005-01-01" @default.
- W2361892106 modified "2023-09-26" @default.
- W2361892106 title "To Explore the Effect of Naloxone on Alcoholic Fatty Liver in Rats" @default.
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