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- W2361898153 abstract "Objective:To investigate the effect of the compound prescription named as baoganning made of chinese traditional medicine on proliferation of hepatic stellate cells(HSCs) actived by leptin,we try to clarify the mechanisms that baoganning resisted haptic fibrosis.Methods:Normal wistar rats were medicated with baoganning decoction by gavage for 7 days to prepare baoganning drug-serum.The effect of baoganning drug-serum on 100 ng/ml leptin activing HSC-LX2 growth was measured by MTT assay;P-JAK2 at different time after baoganning stimulation was detected by Western blotting analysis.Results:Compared to the blank control,P-JAK2 began to descend at 6h after the serum with baoganning ingredients treating HSC-LX2 and JAK2 reached to the lowest level at 12h.Compared to the blank control,baoganning ingredients treating HSC-LX2 which was excelled compared with colchicine ingredients.Conclusion:Baoganning could inhibit P-JAK2,and the one of the mechanisms baoganning preventing Hepatic fibrosis may be because inhibiting P-JAK2." @default.
- W2361898153 created "2016-06-24" @default.
- W2361898153 creator A5064332635 @default.
- W2361898153 date "2008-01-01" @default.
- W2361898153 modified "2023-09-24" @default.
- W2361898153 title "Experimental study on the proliferation of HSC indcued by recombinant leptin and the regulation and control action of baoganning" @default.
- W2361898153 hasPublicationYear "2008" @default.
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