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- W2361898839 abstract "To investigate the effect of infection with Toxoplasma gondii on the expression levels of materno-fetal interface cytokine transcription and to explore the immune mechanisms in abnormal pregnancy induced by T.gondii,14 villi and ducidual explants were obtained from induced abortions of normal pregnancies from 5 to 10 weeks,in which the trophoblastic cells were(isolated) from villous tissues,and the NK cells were separated from decidual tissues.The trophoblastic cells and NK cells were divided into experimental and control groups,in which the experimental group was infected with T.gondii,and the control group without infection. After being incubated for 48 hours,the expression of IL-4 and IL-10 mRNA as well as IFN-γ mRNA in ducidual NK cells were analyzed with quantitative real-time PCR.Experimental rsults showed that the average expression levels of IL-4,IL-10 and IFN-γ mRNA in trophoblastic and NK cells were(0.05±0.02),(0.06±0.03),(0.33±0.09) respectively in the experimental group;while those in the control group were(0.31±0.13),(0.18±0.06),(0.08±0.03) respectively.The differences in these groups were quite significant(P0.05,P0.01,P0.05).The average ratio of IFN-γ/IL-10 and IFN-γ/IL-4 in the experimental group were(3.96±0.84) and(3.21±0.41),but they were(0.06±0.21) and(0.78±0.25) respectively.From the above observations,it is evident that during the early stage of pregnancy infected with T.gondii the expressions of materno-fetal interface Th1-type cytokines increase,with a reduced expression of the Th2-type cytokines,thus interfering the normal Th1/Th2 balance that is required for the maintanance of normal prognancy." @default.
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- W2361898839 date "2006-01-01" @default.
- W2361898839 modified "2023-09-26" @default.
- W2361898839 title "Effect of infection with Toxoplasma gondii on the expression levels of materno-fetal interface cytokine transcription" @default.
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