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- W2361914083 abstract "Objective To find the characteristics of metabolic changes in neuroanatomical circuit in patients with first-episode obsessive-compulsive disorder through 1H-MRS. Methods Twenty patients with first-episode obsessive-compulsive disorder(the study group) and twenty gender- and age-matched normal controls(the control group) were involved in the study. The neurochemical abnormalities including the levels of choline(Cho)/creatine(Cr), N-acetylaspartate(NAA)/Cr were measured respectively in prefrontal lobe, anterior cingutate, orbital frontal lobe, caudate nucleus and thalamus with three-dimension 1H-proton magnetic resonance spectroscopy(3D 1H-MRS). Results The values of Cho/Cr ratios in thalamus were significant higher in the study group than the control group(P0.01), and the values of NAA/Cr in caudate nucleus, thalamus were significantly lower in the study group(P 0.01), but the values of NAA/Cr in anterior cingutate, orbital frontal lobe were higher(P0.01). Conclusion There are some special neurochemical and histological structure changes(cortico-striatal-thalamic-cortical cycle) in first-episode obsessive-compulsive disorder. 1H-MRS can find these changes through assessing the metabolic abnormalities." @default.
- W2361914083 created "2016-06-24" @default.
- W2361914083 creator A5055084879 @default.
- W2361914083 date "2014-01-01" @default.
- W2361914083 modified "2023-09-23" @default.
- W2361914083 title "Study of neuroanatomical circuit in first-episode obsessive-compulsive disorder by magnetic resonance spectroscopy" @default.
- W2361914083 hasPublicationYear "2014" @default.
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