Matches in SemOpenAlex for { <https://semopenalex.org/work/W2361939923> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2361939923 abstract "Objective:To investigate the effects of DOC-2 gene on proliferation,ultrastructure,and cell cycle of ovarian cancerous HO-8910 cells and the corresponding mechanism. Methods:HO-8910 cells were divided into three groups:HO-8910 group,8910-P93 group(transfected with DOC-2 gene),and 8910-pcDNA3.1 group(transfected with the vector of pcDNA3.1). The cell proliferation was determined with cell counting methods and [3H]TdR incorporation was used to measure the DNA synthesis. The ultrastructures of cells were observed through transmission electron microscope. The cell cycle was analyzed by flow cytometry before and after DOC-2 gene transfection. Results:DOC-2 gene transfection markedly inhibited the proliferation and DNA synthesis of HO-8910 cells(P0.05).There was no difference in cell proliferation and DNA synthesis between the 8910-pcDNA3.1 and HO-8910 group. Cells in 8910-P93 group showed the signs of pre-apoptosis:dilated rough endoplasmic reticulum,vacuolated mitochondria, and increased lysosome and marginated chromatin in some cells. Flow cytometry analysis showed that the cell proportions in G1 and G2 phase were significantly increased and that in the S phase was decreased markedly. Conclusion:Tumor suppressor gene DOC-2 inhibits the proliferation of ovarian cancer HO-8910 cells via inducing morphological changes and cell cycle arrest." @default.
- W2361939923 created "2016-06-24" @default.
- W2361939923 creator A5069041636 @default.
- W2361939923 date "2006-01-01" @default.
- W2361939923 modified "2023-09-25" @default.
- W2361939923 title "Effect of tumor suppressor gene DOC-2 on proliferation of human ovarian cancer cells" @default.
- W2361939923 hasPublicationYear "2006" @default.
- W2361939923 type Work @default.
- W2361939923 sameAs 2361939923 @default.
- W2361939923 citedByCount "0" @default.
- W2361939923 crossrefType "journal-article" @default.
- W2361939923 hasAuthorship W2361939923A5069041636 @default.
- W2361939923 hasConcept C1491633281 @default.
- W2361939923 hasConcept C153911025 @default.
- W2361939923 hasConcept C190283241 @default.
- W2361939923 hasConcept C29537977 @default.
- W2361939923 hasConcept C54009773 @default.
- W2361939923 hasConcept C54355233 @default.
- W2361939923 hasConcept C552990157 @default.
- W2361939923 hasConcept C553184892 @default.
- W2361939923 hasConcept C55493867 @default.
- W2361939923 hasConcept C62112901 @default.
- W2361939923 hasConcept C64241487 @default.
- W2361939923 hasConcept C81885089 @default.
- W2361939923 hasConcept C86803240 @default.
- W2361939923 hasConcept C95444343 @default.
- W2361939923 hasConceptScore W2361939923C1491633281 @default.
- W2361939923 hasConceptScore W2361939923C153911025 @default.
- W2361939923 hasConceptScore W2361939923C190283241 @default.
- W2361939923 hasConceptScore W2361939923C29537977 @default.
- W2361939923 hasConceptScore W2361939923C54009773 @default.
- W2361939923 hasConceptScore W2361939923C54355233 @default.
- W2361939923 hasConceptScore W2361939923C552990157 @default.
- W2361939923 hasConceptScore W2361939923C553184892 @default.
- W2361939923 hasConceptScore W2361939923C55493867 @default.
- W2361939923 hasConceptScore W2361939923C62112901 @default.
- W2361939923 hasConceptScore W2361939923C64241487 @default.
- W2361939923 hasConceptScore W2361939923C81885089 @default.
- W2361939923 hasConceptScore W2361939923C86803240 @default.
- W2361939923 hasConceptScore W2361939923C95444343 @default.
- W2361939923 hasLocation W23619399231 @default.
- W2361939923 hasOpenAccess W2361939923 @default.
- W2361939923 hasPrimaryLocation W23619399231 @default.
- W2361939923 hasRelatedWork W2273578390 @default.
- W2361939923 hasRelatedWork W2295553756 @default.
- W2361939923 hasRelatedWork W2349945840 @default.
- W2361939923 hasRelatedWork W2352428587 @default.
- W2361939923 hasRelatedWork W2385502232 @default.
- W2361939923 hasRelatedWork W2403998404 @default.
- W2361939923 hasRelatedWork W2417034418 @default.
- W2361939923 hasRelatedWork W2750728167 @default.
- W2361939923 hasRelatedWork W2900410042 @default.
- W2361939923 hasRelatedWork W3024747235 @default.
- W2361939923 hasRelatedWork W3029234310 @default.
- W2361939923 hasRelatedWork W3030229242 @default.
- W2361939923 hasRelatedWork W3030275518 @default.
- W2361939923 hasRelatedWork W3030622382 @default.
- W2361939923 hasRelatedWork W3032379263 @default.
- W2361939923 hasRelatedWork W3032442102 @default.
- W2361939923 hasRelatedWork W3143981724 @default.
- W2361939923 hasRelatedWork W3147208470 @default.
- W2361939923 hasRelatedWork W3150856836 @default.
- W2361939923 hasRelatedWork W3031479171 @default.
- W2361939923 isParatext "false" @default.
- W2361939923 isRetracted "false" @default.
- W2361939923 magId "2361939923" @default.
- W2361939923 workType "article" @default.