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- W2361940504 abstract "【Objective】 To test the expression of IL-6 in spinal dorsal horn and evaluate its effects on the development of neuropathic pain induced by L5 ventral root transection(L5-VRT).【Method】 Rats mechanical allodynia model was prepared by L5-VRT.The expression and cellular localization of IL-6 in spinal dorsal horn was detected by Western blot and immunofluorescence staining.The behavioral test was used to observe the affection of the neutralizing antibody of IL-6 on the mechanical allodynia induced by L5 VRT.【Result】 The expression of IL-6 in neurons was upregulated in ipsilateral DRGs on day 7 after surgery(P 0.001).Intrathecal injection of the neutralizing antibody of IL-6 administered 30 min before L5-VRT effectively attenuated bilateral mechanical allodynia induced by L5 VRT(P 0.05).【Conclusion】 IL-6 participates in regulation of the rat mechanical allodynia induced by motor nerve injury." @default.
- W2361940504 created "2016-06-24" @default.
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- W2361940504 date "2012-01-01" @default.
- W2361940504 modified "2023-09-26" @default.
- W2361940504 title "Involvement of IL-6 in Neuropathic Pain Rats Following Motor Nerve Injury" @default.
- W2361940504 hasPublicationYear "2012" @default.
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