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- W2361950596 abstract "BACKGROUND AIM: To explore the correlation between up-regulated expressions of Survivin and P53 proteins in the tumor tissues and relapse of transitional cell carcinoma (TCC) of the bladder. MATERIALS AND METHODS: Survivin and P53 proteins in the paraffin-embedded tumor tissues derived from 75 cases of TCC were examined by immunohistochemical staining. The expressions of the two proteins and the pathological grading were assessed, using Mantel-Haenszel analysis to calculate the odds ratios and significance level for difference of the indicators between the relapse and non-relapse groups of the TCC patients. RESULTS: The positive staining rates of Survivin in cytoplasm, Survivin in nuclei, P53, and cytoplasmic Survivin plus P53 were 76.0% , 30.67% , 53.33% and 84.0% , respectively. The sensitivity for predicting the relapse were 87.50% , 37.50% , 71.88% and 96.88% , respectively. The specificities were 32.56% , 74.42% , 61.90% and 25.58% , respectively. The relative risks for the relapse were as following, Survivin (cytoplasm): OR=3.38, 95% CI (0.99- 11.52), P=0.044; P53: OR=3.91, 95% CI (1.46- 10.45), P=0.005; Survivin plus P53: OR=10.66, P=0.0087. The odds ratios by pathological grading classification were, P53: OR=3.41, P=0.016; P53 plus Survivin: OR=8.86, P=0.022. CONCLUSION: Over-expression of P53 protein in the tumor tissues might suggest a high risk for recurrence of bladder TCC, whereas the association between overexpression of Survivin and relapse of TCC was not demonstrated." @default.
- W2361950596 created "2016-06-24" @default.
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- W2361950596 date "2006-01-01" @default.
- W2361950596 modified "2023-10-03" @default.
- W2361950596 title "Correlation Between Expressions of Survivin and P53 Proteins and Relapse of Transitional Cell Carcinoma of Bladder" @default.
- W2361950596 hasPublicationYear "2006" @default.
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