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- W2361951752 abstract "OBJECTIVE:To study the effect of lipide diet on pharmacokinetics of moxifloxacin.METHODS:In randomized crossover experiment,8 Beagle dogs were given moxifloxacin 17 mg·kg-1 at the condition of empty stomach or after lipide diet for 1 week.Plasma concentration of moxifloxacin was determined by HPLC at different time(during 72 h).The pharmacokinetic parameters were calculated by 3p97 software.RESULTS:The plasma concentration-time curves were two or one compartment model at the condition of empty stomach or after lipide diet.Main pharmacokinetic parameters were as follows:t1/2β(t1/2ke):(24.89±6.77) h vs.(12.32±2.96) h;tmax:(2.00±0.76) h vs.(9.00±1.85) h;Cmax:(7.0±0.67) μg·mL-1 vs.(4.16±1.32) μg·mL-1;AUC0～t:(84.30±10.86) μg·h·mL-1 vs.(85.78±27.38) μg·h·mL-1,respectively.There were significant differences in pharmacokinetic parameters except for AUC0～t(P0.01).CONCLUSION:Lipide diet can delay the absorption of moxifloxacin and inhibit its antibacterial activity." @default.
- W2361951752 created "2016-06-24" @default.
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- W2361951752 date "2010-01-01" @default.
- W2361951752 modified "2023-09-26" @default.
- W2361951752 title "Effect of Lipide Diet on the Pharmacokinetics of Moxifloxacin in Dogs" @default.
- W2361951752 hasPublicationYear "2010" @default.
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