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- W2361962589 abstract "Objective To investigate genetic association betw een N-acetyltransferase-2( NAT2) gene polymorphism and colorectal cancer( CRC). Methods A hospital-based 1: 2 matched case-control study and PCR-based ligase detection reaction( PCR-LDR) w ere applied to tag single nucleotide lengh polymorphism( SNPs) of NAT2 gene among 104 cases w ith colorectal cancer and 208 controls. Results The genotypic frequency of tag SNPs of NAT2 gene did not deviate from Hardy-Weinberg equilibrium in both case and control groups. Rs1799931 w as not associated w ith colorectal cancer( P 0. 05),but rs1799929 and rs1799930 were related to colorectal cancer( P 0. 05). The case group had more T allele of rs1799929 and A allele of rs1799930 w hen compared to the controls; w hile T allele of rs1799929 and A allele of rs1799930 seemed to be the risk factors of colorectal cancer( odds ratio [OR] = 2. 069,P = 0. 004; OR = 1. 431,P = 0. 004). The frequency of NAT2 slow genotype w as 43. 3% in the cases compared w ith 26. 0% in the controls. As compared w ith the NAT2 rapid genotypes,the NAT2 slow genotype significantly increased the risk of developing colorectal cancer,w ith an OR of 1. 667( 95% confidence interval: 1. 213- 2. 291). Conclusion The results suggest that NAT2 genetic polymorphism is associated w ith colorectal cancer susceptibility. People w ith NAT2 slow genotype have a higher risk of colorectal cancer." @default.
- W2361962589 created "2016-06-24" @default.
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- W2361962589 date "2015-01-01" @default.
- W2361962589 modified "2023-09-24" @default.
- W2361962589 title "Association between polymorphism of NAT2 and risk of colorectal cancer" @default.
- W2361962589 hasPublicationYear "2015" @default.
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