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- W2361963180 abstract "Objective To explore the possible mechanism which was involved in the regulatory action of diabetes in vascular calcification.Methods Rat vascular calcific model were induced by vitamin D3 intramuscular injection and oral nicotine;diabetic rat model were induced by streptozocin(STZ) intraperitoneal injection for once.The total aorta Ca2+ content in aorta was measured by atom absorptive spectrophotography;the alkaline phosphatase(ALP) activity in plasma and aorta;and the levels of osteocalcin(OC),tumor necrosis factor(TNF) in plasma and aorta were determined by radioimmunoassay.Results Many black granules among the smooth muscle cells and its matrix in calcified aorta by Von Kossa staining in VDN group was observed;1.98-fold,2.83-fold,84.12% increase Calcium,ALP and OC were observed in VDN group and more than that in control group,respectively;TNF level of aortic was significantly increased(P0.01).The calcification in aorta was significantly promoted by diabetic rat model induced by streptozocin(STZ).When diabetes was happening,the total aorta Ca2+ contents,ALP activity,and OC levels were more respectively than those in the rats with vascular calcification.Diabetes treatment significantly increased TNF level(P 0.01).Conclusion Results indicated that diabetes can significantly promote the calcification in aorta partly through the cooperation with TNF system in circulation and vascular tissues." @default.
- W2361963180 created "2016-06-24" @default.
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- W2361963180 date "2009-01-01" @default.
- W2361963180 modified "2023-09-25" @default.
- W2361963180 title "Effect of Diabetes on Vascular Calcification in Diabetic Rat" @default.
- W2361963180 hasPublicationYear "2009" @default.
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