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- W2361963812 abstract "Aim: To study how the combined use of amiodarone with Ibutilide effects on myocardial transmural dispersion of repolarization( TDR),and whether the combined use of Ibutilide with amiodarone is able to reduce the side effects compared with the use of Ibutilide alone. Methods: 35 New Zealand rabbits were randomly divided into control group,Ibutilide group A( perfused with normal tyrode's solution containing 2 mg / L Ibutilide),Ibutilide group B( perfused with hypopotassemia and hypomag-nesemia tyrode's solution containing 2 mg / L Ibutilide),amiodarone( 50 mg / kg amiodarone orally given every day for 4 weeks) combined with Ibutilide group A( perfused with normal tyrode's solution containing 2 mg / L Ibutilide),amiodarone( 50mg / kg amiodarone orally given every day for 4 weeks) combined with Ibutilide group B( perfused with hypopotassemia and hypomagnesemia tyrode's solution containing 2 mg / L Ibutilide),with 7 rabbits in each group. The left ventricular wedge preparations were made for each group. Transmural ECG and action potentials from both endocardium and epicardium were simultaneously recorded. The changes of TDR and Tdp were analyzed. Results: In this study,TDR level was found to be increased to 50. 42 ± 4. 2 ms in Ibutilide group A and 67. 12 ± 12. 62 ms in Ibutilide group B, significantly higher than the control group. Amiodarone was found to be able to decrease TDR level to 16. 8 ± 3. 3 ms in both amiodarone combined with Ibutilide group A and B. Based on the results,Ibutilide was used after the administration of amiodarone,and it was found that TDR level maintained at 27. 22 ± 5. 1 ms in amiodarone combined with Ibutilide group A,and 32. 21 ± 5. 2 ms in amiodarone combined with Ibutilide group B,significantly lower than that of the control group. In the arrhythmias experiment, we observed that arrhythmia occurred significantly less in amiodarone group B( 0 /7) than Ibutilide group B( 5 /7). Conclusion: Amiodarone may be given orally for a period of time or up to 4 weeks before Ibutilide is given,which can effectively lower the risk of Tdp that might be caused by Ibutilide. This might improve the safety of Ibutilide." @default.
- W2361963812 created "2016-06-24" @default.
- W2361963812 creator A5030616332 @default.
- W2361963812 date "2014-01-01" @default.
- W2361963812 modified "2023-09-26" @default.
- W2361963812 title "The cardiac electrophysiological mechanism research for use of Ibutilide after the application of amiodarone" @default.
- W2361963812 hasPublicationYear "2014" @default.
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