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- W2361981182 abstract "Objective To investigate whether the EBV infection,expression of mutant p53 protein and bcl-2 protein involve in the development and progression of nasopharyngeal carcinogenesis.Methods Tissue microarray technique combined with immunohistochemistry and in situ hybridization were used to detect the expression of EBER-1(EBV-encoded small RNA,EBER-1)hybridization signals,mutant p53 protein and bcl-2 protein in tissues of nasopharyngeal carcinogenesis process with differently pathological morphology.Results(1) EBER-1 positive hybridization signals and positive expression of mutant p53 and bcl-2 proteins were significantly increased in NPC compared with histologically normal nasopharyngeal epithelium(NPE) and hyperplastic NPE(P0.01);EBER-1 and p53 protein in NPC were significantly higher than that in the dysplastic NPE(P0.01);EBER-1 positive hybridization signals and positive expression of bcl-2 proteins were significantly increased in the dysplastic NPE compared with and hyperplastic NPE and histologically normal NPE(P0.01);further statistic analysis confirmed that expression of p53 in the dysplastic NPE and hyperplastic NPE was higher than that in the normal NPE(P0.05).(2) Expression of p53 and bcl-2 proteins in clinical T3 and T4-staged NPC was evidently higher than that in T1 and T2-staged NPC(P=0.005,P=0.023,respectively);EBER-1 had significantly positive correlations with p53 and bcl-2(P0.01),also,p53 had evidently positive correlations with bcl-2 protein expression in NPC(P0.01).(3) Agreement rate,sensitivity,specificity,negative predictive values and positive predictive values,which were used to evaluate practical values of molecular markers to distinguish NPC from the non-cancerous NPE,revealed that combined application of molecular phenotype,EBER-1 and/or p53 protein over-expression was the best molecular approach.Conclusion Abnormal expression of p53 protein in the early stage of nasopharyngeal carcinogenesis following infection of EBV and activation of bcl-2 gene by restraining apoptosis and continuously proliferation of nasopharyngeal epithelium,may play a role in finally resulting in development of NPC.Combined molecular phenotype,EBER-1 positive and/or p53 protein over-expression,is the best molecular approach for distinguishing NPC from the non-cancerous NPE." @default.
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- W2361981182 date "2008-01-01" @default.
- W2361981182 modified "2023-09-23" @default.
- W2361981182 title "Role of EBV in nasopharyngeal carcinogenesis:a tissue microarray study" @default.
- W2361981182 hasPublicationYear "2008" @default.
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