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- W2361984972 abstract "Objective To observe the effects of colchicine on renal interstitial fibrosis in rats with unilateral ureteral obstruction (UUO).Methods 26 Sprague Dawley rats were divided into three groups:the colchicine treated group (10 rats):UUO+colchicine 100μg/(kg·d) by intraperitoneally(I.P) for 5 days per week,the saline treated group (10 rats):UUO+saline 100μg/(kg·d) by I.P for 5 days per week,and control group (6 rats).All rats were put to death at three weeks and the renal samples were used in morphological research.Results The numbers of inflammatory cells infiltration in colchicine treated group rats significantly decreased compared to that in saline treated group (1*#738 44 ±910 87 cells/mm 2 vs. 6*#322 05 ± 1*#198 18 cells/mm 2, P 0 001).The index of interstitial fibrosis in colchicine treated rats also significantly reduced compared to that in saline treated rats (22 67±17 61 vs.72 92±9 86, P 0 001).Meanwhile,the tubular lesions in saline treated rats were severer than that in colchicine treated rats (2 47±0 47 vs.1 43±0 65 P 0 05).Conclusion Colchicine had beneficial effects on interstitial fibrosis in rats with UUO Sprague Dawley." @default.
- W2361984972 created "2016-06-24" @default.
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- W2361984972 date "2002-01-01" @default.
- W2361984972 modified "2023-09-27" @default.
- W2361984972 title "A morphological study for the effects of colchicine on renal interstitial fibrosis in rats with unilatera ureteral obstruction" @default.
- W2361984972 hasPublicationYear "2002" @default.
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