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- W2361996670 abstract "[Objective] To discussion the effect of atorvastatin intervention on serum endothelin(ET) and vascular cell adhesion molecule-1(VCAM-1) on patients with acute coronary syndrome.[Methods] The serum ET level and VCAM-1 level were determinated by radioimmunity and ELISA methods respectively in 76 cases of ACS patients and 40 cases of healthy control.At the same time,ACS patients were randomly divided into atorvastatin group(atorvastatin 10mg /d,n=38) and control group(conventional treatment,n=38).Before and after atorvastat treatment,the serum ET level and VCAM-1 level were measured,which were compared before and after treatment,and groups.[Results](1) When Compared with the control group,the serum ET level and VCAM-1 level were significantly increased in ACS patients(all P﹤0.01).In atorvastatin group and control group,the serum ET level and VCAM-1 level significantly decreased after 2 weeks treatment.Compared with the control group,the serum ET level and VCAM-1 level were significantly lower in the atorvastatin group(all P﹤0.01).[Conclusion] Increase of ET level and VCAM-1 level in ACS patients plays an important role on the inflammatory response in the atherosclerotic plaque.Statin drugs such as atorvastatin can modulate endothelium injury and proinflammatory cytokine levels,such as reducing serum ET level and VCAM-1 level,and then reduce inflammation within the plaque in patients with ACS." @default.
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- W2361996670 date "2010-01-01" @default.
- W2361996670 modified "2023-09-28" @default.
- W2361996670 title "Effect of atorvastatin on serum endothelin and vascular cell adhesion molecule-1 on patients with acute coronary syndrome." @default.
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