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- W2362013309 abstract "Objective To develop cisplatin-loaded long-circulating liposomes modified with transferrin(Tf-PEG-CDDP).Methods The blank liposomes were prepared by thin film dispersion-ultrasound method and cisplatin was packaged by ammonium sulfate gradient method.Tf-PEG-CDDP was prepared by binding transferrin to maleimide terminal of DSPE-PEG_(2000)-MAL.Free cisplatin and cisplatin liposomes were separated by ultrafiltration.The encapsulation efficiency of Tf-PEG-CDDP was determined with UV-Vis spectrophotometer.The size was detected by laser scattering particle size analyzer and the physical properties were observed by transmission electron microscopy.Dialysis was used to study the release of cisplatin in vitro.Results Electron microscopy demonstrated that Tf-PEG-CDDP was round vesicle-like structure and the size was slightly uneven with an average particle size of 200 nm.The mean cisplatin encapsulation efficiency of liposomes was(78.222±5.4086)%.In vitro release test showed that the slow-release property of Tf-PEG-CDDP was significantly better than that of CDDP.Conclusion The cisplatin-loaded liposomes modified with transferrin Tf-PEG-CDDP has been successfully developed with a satisfactory slow-release property." @default.
- W2362013309 created "2016-06-24" @default.
- W2362013309 creator A5019602015 @default.
- W2362013309 date "2011-01-01" @default.
- W2362013309 modified "2023-09-25" @default.
- W2362013309 title "Preparation of cisplatin-loaded long-circulating liposomes modified with transferrin" @default.
- W2362013309 hasPublicationYear "2011" @default.
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