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- W2362014562 abstract "Objective To investigate the biological effects of CD40 ligation on proliferation of lung cancer cell lines NCI-H460, A549, SPC-A-1 and the changes of tumor necrosis factor receptors (TNFR) as well as tumor necrosis factor receptor associated factor (TRAP) after CD40 ligation. Methods MTT assay was used to determine the proliferation of tumor cells after CD40L had been added. Immunofluorescence technique and flow cytometry were used to detect the expression of CD40 on cell surface and the changes of TNFR and TRAP expression after CD40 ligation. Results 1. The expression of CD40 on cell lines varied from(2. 3±0. 3)% to(89. 2±3. 2)%. 2. There was an inhibition of cell proliferation on CD40 positive cell lines NCI-H460 and A549 after CD40 ligation while no inhibition was observed on CD40 negative cell line SPC-A-1. 3. There was an up-regulation of TNFR Ⅰ together with a down-regulation of TNFR Ⅱ expression on NCI-H460 and A549, while no changes were observed on SPC-A-1. 4. The expression of TRAF2,3,5,6 in NCI-H460 and A549,but not in SPC-A-1 was down regulated after CD40 ligation. Conclusion CD40 ligation could inhibit cell proliferation of CD40 positive cell lines NCI-H460 and A549 and cause changes of TNFR and TRAP expression. These changes indicate that CD40 signal has an important adjustive function on CD40 positive cell lines." @default.
- W2362014562 created "2016-06-24" @default.
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- W2362014562 date "2004-01-01" @default.
- W2362014562 modified "2023-09-26" @default.
- W2362014562 title "Biological effects of CD40 ligation on tumor necrosis factors and their associated factors expressed in lung cancer cell lines" @default.
- W2362014562 hasPublicationYear "2004" @default.
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