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- W2362020002 abstract "Objective To investigate the effects of borneol and ursodesoxycholic acid on the corneal permeability of baicalin in vitro,and to discuss their application in ocular preparation.Methods The effects of borneol and ursodesoxycholic acid with different concentration on the corneal permeability of baicalin were investigated in vitro using the isolated corneal penetration technology.Results Borneol(0.2 mg/mL) could significantly increase the apparent permeability(Papp) of baicalin in 1.36-fold compared with the control group(P 0.05).Borneol(0.3,0.4,0.5,and 0.7 mg/mL) could increase the Papp of baicalin in 1.35-,1.43-,1.51-,and 3.47-folds,respectively,and ursodesoxycholic acid(0.2,0.3,0.4,0.5,and 0.7 mg/mL) could significantly increase the Pappof baicalin in 1.19-,2.25-,1.24-,0.35-,and 0.68-folds,respectively compared with the control group(P 0.01).Conclusion Borneol and ursodesoxycholic acid(0.2,0.3,0.4,0.5,and 0.7 mg/mL) could significantly increase the Papp of baicalin without stimulation on rabbit cornea." @default.
- W2362020002 created "2016-06-24" @default.
- W2362020002 creator A5090480943 @default.
- W2362020002 date "2013-01-01" @default.
- W2362020002 modified "2023-09-25" @default.
- W2362020002 title "Effects of borneol and ursodesoxycholic acid on corneal permeability of baicalin" @default.
- W2362020002 hasPublicationYear "2013" @default.
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