Matches in SemOpenAlex for { <https://semopenalex.org/work/W2362022674> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2362022674 abstract "Objective To examine the effect of zinc finger protein A20 on regeneration of small-for-sized liver allograft, graft rejection and recipient rat survival time. Methods Small-for-sized liver transplantation with 30% partial liver allograft was performed by using a strong-rejection combination rat model of DA (RT1a) to Lewis (RT1l) rats. The rats were grouped into rAdEasy-A20 treatment group (A20 group), the control empty Ad vector rAdEasy treatment group (rAdEasy group) and PS control treatment group (PS group). Ex vivo gene transfer in donor liver graft was performed through portal vein infusion. Animals were assessed for survival days, expression of A20 in liver graft, liver graft regeneration, hepatocyte apoptosis, graft rejection, NF-κB activation and ICAM-1 mRNA expression in liver graft sinusoidal endothelial cells (LSECs), number of liver graft infiltrating mononuclear cells (LIMCs) and the subproportion of NK/NKT cells, and serum IFN-γ level. Results Survival day of A20 group rats was prominently longer than that of PS group rats and rAdEasy group rats (P=0.001 8), whereas survival day of rAdEasy group rats was remarkably shorter than that of PS group rats (P=0.001 8). Regeneration of the small-for-sized liver allograft was markedly augmented by A20, BrdU labelling index of hepatocyte on postoperative day 4 was significantly increased in the A20 group compared with the PS group and rAdEasy group (P0.01). Hepatocyte apoptosis on postoperative day 4 was significantly inhibited by A20 (P0.01). On postoperative day 4, histologic examination revealed a mild rejection in the A20 group but a more severe rejection in the PS and rAdEasy groups. NF-κB activity and ICAM-1 mRNA expression in LSECs on postoperative day 1 were notably suppressed by A20 overexpression. Flow cytometry analysis showed a marked downregulation of LIMCs number by A20, including more prominent decrease in the subproportion of NK/NKT cells on postoperative day 1 and 4, respectively (P0.05). Serum IFN-γ level on postoperative day 4 was also significantly suppressed by A20 overexpression (P0.05). Conclusion These data suggest that A20 could effectively promote small-for-sized liver allograft regeneration, suppresses rejection and prolong survival days of recipient rats. These effects of A20 could be related to an inhibition of LSECs activation, suppression of infiltration of LIMCs and the subpopulations such as NK cells and NKT cells into liver graft, and inhibition of hepatocyte apoptosis." @default.
- W2362022674 created "2016-06-24" @default.
- W2362022674 creator A5068435349 @default.
- W2362022674 date "2008-01-01" @default.
- W2362022674 modified "2023-09-22" @default.
- W2362022674 title "Zinc Finger Protein A20 Promotes Regeneration of Small-for-Sized Liver Allograft and Suppresses Rejection in Rats" @default.
- W2362022674 hasPublicationYear "2008" @default.
- W2362022674 type Work @default.
- W2362022674 sameAs 2362022674 @default.
- W2362022674 citedByCount "0" @default.
- W2362022674 crossrefType "journal-article" @default.
- W2362022674 hasAuthorship W2362022674A5068435349 @default.
- W2362022674 hasConcept C126322002 @default.
- W2362022674 hasConcept C134018914 @default.
- W2362022674 hasConcept C137061746 @default.
- W2362022674 hasConcept C142724271 @default.
- W2362022674 hasConcept C16685009 @default.
- W2362022674 hasConcept C171056886 @default.
- W2362022674 hasConcept C190283241 @default.
- W2362022674 hasConcept C202751555 @default.
- W2362022674 hasConcept C203014093 @default.
- W2362022674 hasConcept C204232928 @default.
- W2362022674 hasConcept C2776200302 @default.
- W2362022674 hasConcept C2776795407 @default.
- W2362022674 hasConcept C2779609443 @default.
- W2362022674 hasConcept C2911091166 @default.
- W2362022674 hasConcept C55493867 @default.
- W2362022674 hasConcept C71924100 @default.
- W2362022674 hasConcept C86803240 @default.
- W2362022674 hasConcept C90924648 @default.
- W2362022674 hasConcept C95444343 @default.
- W2362022674 hasConceptScore W2362022674C126322002 @default.
- W2362022674 hasConceptScore W2362022674C134018914 @default.
- W2362022674 hasConceptScore W2362022674C137061746 @default.
- W2362022674 hasConceptScore W2362022674C142724271 @default.
- W2362022674 hasConceptScore W2362022674C16685009 @default.
- W2362022674 hasConceptScore W2362022674C171056886 @default.
- W2362022674 hasConceptScore W2362022674C190283241 @default.
- W2362022674 hasConceptScore W2362022674C202751555 @default.
- W2362022674 hasConceptScore W2362022674C203014093 @default.
- W2362022674 hasConceptScore W2362022674C204232928 @default.
- W2362022674 hasConceptScore W2362022674C2776200302 @default.
- W2362022674 hasConceptScore W2362022674C2776795407 @default.
- W2362022674 hasConceptScore W2362022674C2779609443 @default.
- W2362022674 hasConceptScore W2362022674C2911091166 @default.
- W2362022674 hasConceptScore W2362022674C55493867 @default.
- W2362022674 hasConceptScore W2362022674C71924100 @default.
- W2362022674 hasConceptScore W2362022674C86803240 @default.
- W2362022674 hasConceptScore W2362022674C90924648 @default.
- W2362022674 hasConceptScore W2362022674C95444343 @default.
- W2362022674 hasLocation W23620226741 @default.
- W2362022674 hasOpenAccess W2362022674 @default.
- W2362022674 hasPrimaryLocation W23620226741 @default.
- W2362022674 hasRelatedWork W1239662889 @default.
- W2362022674 hasRelatedWork W1593015928 @default.
- W2362022674 hasRelatedWork W1995130036 @default.
- W2362022674 hasRelatedWork W2039719529 @default.
- W2362022674 hasRelatedWork W2132430900 @default.
- W2362022674 hasRelatedWork W2181899572 @default.
- W2362022674 hasRelatedWork W2355916151 @default.
- W2362022674 hasRelatedWork W2372640396 @default.
- W2362022674 hasRelatedWork W2403472718 @default.
- W2362022674 hasRelatedWork W2751934111 @default.
- W2362022674 hasRelatedWork W2753204193 @default.
- W2362022674 hasRelatedWork W3024719938 @default.
- W2362022674 hasRelatedWork W3029231432 @default.
- W2362022674 hasRelatedWork W3029821729 @default.
- W2362022674 hasRelatedWork W3029944927 @default.
- W2362022674 hasRelatedWork W3031539961 @default.
- W2362022674 hasRelatedWork W3031644075 @default.
- W2362022674 hasRelatedWork W3031944864 @default.
- W2362022674 hasRelatedWork W3032095548 @default.
- W2362022674 hasRelatedWork W3032161389 @default.
- W2362022674 isParatext "false" @default.
- W2362022674 isRetracted "false" @default.
- W2362022674 magId "2362022674" @default.
- W2362022674 workType "article" @default.