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- W2362029852 abstract "Objective To investigate the immunoregulatory effect of plasmid expressing human interleukin 2 on paramyosin(AgB) DNA vaccine. Methods Recombinant plasmid pcDNA3 IL 2 was constructed by inserting full length human interleukin 2 cDNA into eukaryotic expression vector pcDNA3. C57BL/6 mice were injected intramuscularly with nucleic acid vaccines(including pcDNA3 group, AgB group, combined immunization group). Specific IgG and IgG2a in serum were tested by ELISA. T H cell proliferation and IL 2, IL 4 secreted by splenocytes were determined by MTT method and ELISA kit, respectively. Then challenge trial was performed in newborn pigs. Results Injection of AgB DNA vaccine and IL 2 expressing plasmid combination increased the levels of IgG and IgG2a in mouse serum. T H cell proliferation and interleukin 2 secreted by splenocytes were dramatically increased by co injection of IL 2 gene. However, IL 4 level was influenced insignificantly. Co injection with IL 2 gene increased relative protection rate in newborn pigs. Conclusion Human IL 2 gene is a potent adjuvant for paramyosin nucleic acid vaccine." @default.
- W2362029852 created "2016-06-24" @default.
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- W2362029852 date "2002-01-01" @default.
- W2362029852 modified "2023-09-27" @default.
- W2362029852 title "Immunoregulatory effect of plasmid expressing human interleukin-2 on the immune response of paramyosin nucleic acid vaccine" @default.
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