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- W2362033623 abstract "Objective: This article is designed to determine the alterations of Autophagy in 20- months C57BL /6 skeletal muscle with Sarcopenia,to observe the effect of a life-long endurance and resistance exercise on the Autophagy related to genes expression,and to provide some effective ways that can counterwork Sarcopenia for skeletal muscle. Methods: 36 C57BL /6 mice were randomly divided into young control group( YC),older control group( OC),life-long treadmill group( LE),life-long ladder group( LR),9 mice for each group. The age of YC group mice were 3 months and other groups were raised naturally to 20 months. The LE and LR groups were engaged in a treadmill and ladder-climbing training for 17 months respectively. They did exercise once a day and three days a week. Then Real-Time PCR was used to detect the Autophagy related genes LC3,Beclin1 and LAMP- 2 mRNA expression. Results: 1) With the age growing,skeletal muscle mass decreased significantly in natural aging mice, and the Sarcopenia was occurred in these mice. 2) Compared with the YC group,LC3b,LAMP- 2b mRNA expressions were significantly increased in OC group,and LAMP- 2a mRNA expression wasn 't significantly changed. 3) Compared with the OC group,lifelong endurance training significantly increased the ratio of LC3a / LC3b,and decreased Beclin1,LAMP- 2a,LAMP- 2b mRNA expression. 4) Compared with the OC group,lifelong resistance training decreased LC3a,Beclin1,LAMP- 2a mRNA expression,but not significantly; and LC3b mRNA expression decreased significantly. 5) Compared with the LE group,the expressions of Beclin1,LAMP-2a,LAMP- 2b increased a lot. Conclusion: 1) 20 months old C57BL /6 mice can be used as the model animal of Sarcopenia. 2) With the age growing,the autophagy flux increased,protein degradation increased,then lead to Sarcopenia. 3) Lifelong endurance training can effectively inhibit excessive autophagy,thus ease Sarcopenia symptoms. 4) Lifelong resistance training can reduce Autophagic activity and protein degradation in a certain range to prevent the development of sarcopenia. 5) Life-long endurance training had a better effect on the control of excessive autophagy than the life-long resistance training." @default.
- W2362033623 created "2016-06-24" @default.
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- W2362033623 date "2013-01-01" @default.
- W2362033623 modified "2023-09-28" @default.
- W2362033623 title "Effects of Different Exercises Type on Sarcopenia-Associated ATGS Expression in Skeletal Muscle of Natural Aging Mouse" @default.
- W2362033623 hasPublicationYear "2013" @default.
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