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- W2362034103 abstract "Objective:To enhance fibrin glue's strength and anti-biodegradation by using N-(3-dimethylaminopropyl)-N'-ethyl carbodiimide(EDC) to increase its cross-link degree.In order to build the injectable cartilage better.Methods:(1)Use different ratio of fibrinogen and EDC to prepare ideal gel sample.Then analyse the materials' performance by stability testing、the ability of anti-enzyme detection、scanning electron microscopy,with the comparison of the traditional fibrin glue.(2)EDC reacts with fibrinogen to prepare different scaffolds,mixed with the chondrocytes to construct cartilage tissue engineering samples.Construct the control group using traditional fibrin glue.using the LIVE/DEAD Viability /Cytotoxicity Kit to detect the survival situation of the cells in the saffcolds.In the 1th,4th,7th,10th days of the experiment.Results: The fibrin glue cross-linked by EDC used to replace thrombin has a better biological strength and the ability of anti-enzyme,with more closely and orderly three-dimensional porous structure than the traditional fibrin glue,and enhanced as the EDC concentration increases.Cartilage cells grow well in the control group(fibrinogen 200mg/ml+thrombin 100U/ml) and the experimental group(fibrinogen 200mg/ml+EDC 100mg/ml).Conclusions:Fibrin glue cross-linked by EDC of appropriated concentration behaves stronger biological strength and anti-biodegrability than conventional fibrin glue,with more closely and orderly spatial structure.The three-dimensional porous network structure of the modified fibrin glue can also provide adequate space for the cells' growth.The cartilage cells show good viability in the scaffold during the experimental observation period.But high concentrations of EDC are not suitable for cells to survive." @default.
- W2362034103 created "2016-06-24" @default.
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- W2362034103 date "2010-01-01" @default.
- W2362034103 modified "2023-09-24" @default.
- W2362034103 title "Fibrin Glue Cross-Linked with EDC as Injectabl Scaffoldfor Cartilage Engineering" @default.
- W2362034103 hasPublicationYear "2010" @default.
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