Matches in SemOpenAlex for { <https://semopenalex.org/work/W2362034127> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2362034127 abstract "Objective To investigate the therapeutic effects of radioisotope labeled Ku70 antisense oligodeoxynuclecotide(ASODNs) on thyroid carcinoma implanted in nude mice and the related mechanism.Methods The Ku70 ASODNs labeled with 131I was used to treat the tumor-bearing mouse model derived from thyroid carcinoma TT cells.The tumor-forming rate,mortality rate and tumor growth were observed and calculated after treatment with 131I-ASODNs,131I-Na,ASODNs or NS(normal saline).AnnexinⅤ/PI assay was used to examine the apoptosis of tumor cells by flow cytometry.Western blotting analysis was performed to determine the protein expressions of Ku70,proliferating cell nuclear antigen(PCNA,a cell proliferation marker) and Bcl-2(a cell apoptosis marker).Results After treatment with 131I-ASODNs,the Ku70 protein level was down-regulated in the tumor tissues and the growth of tumor was inhibited.The tumor volume,tumor-forming rate and mortality rate were significantly decreased in 131I-ASODNs group than in the NS control group(P 0.01).The tumor volume of 131I-ASODNs group was also significantly smaller than that in the 131I-Na group(P 0.05);the apoptosis rate of 131I-ASODNs group(35.6%) was significantly higher than that of the ASODNs group(10.4%),NS group(9.2%) and 131I-Na group(26.6%)(P 0.05).Further investigation found that PCNA and Bcl-2 protein levels in 131I-ASODNs group were lower than those in NS and ASODNs groups.Conclusion The Ku70 131I-ASODNs can effectively inhibit the growth of thyroid carcinoma and promote apoptosis of TT tumor cells,which might be related to the down-regulation of Ku70 and the changes of PCNA and Bcl-2 signal pathway." @default.
- W2362034127 created "2016-06-24" @default.
- W2362034127 creator A5086470039 @default.
- W2362034127 date "2011-01-01" @default.
- W2362034127 modified "2023-09-26" @default.
- W2362034127 title "Therapeutic effects of radioisotope labeled Ku70 antisense oligodeoxynuclecotide on thyroid carcinoma implanted in nude mice" @default.
- W2362034127 hasPublicationYear "2011" @default.
- W2362034127 type Work @default.
- W2362034127 sameAs 2362034127 @default.
- W2362034127 citedByCount "0" @default.
- W2362034127 crossrefType "journal-article" @default.
- W2362034127 hasAuthorship W2362034127A5086470039 @default.
- W2362034127 hasConcept C134018914 @default.
- W2362034127 hasConcept C142724271 @default.
- W2362034127 hasConcept C153911025 @default.
- W2362034127 hasConcept C190283241 @default.
- W2362034127 hasConcept C204232928 @default.
- W2362034127 hasConcept C2777546739 @default.
- W2362034127 hasConcept C2993294228 @default.
- W2362034127 hasConcept C34688535 @default.
- W2362034127 hasConcept C502942594 @default.
- W2362034127 hasConcept C526584372 @default.
- W2362034127 hasConcept C553184892 @default.
- W2362034127 hasConcept C55493867 @default.
- W2362034127 hasConcept C71924100 @default.
- W2362034127 hasConcept C86803240 @default.
- W2362034127 hasConceptScore W2362034127C134018914 @default.
- W2362034127 hasConceptScore W2362034127C142724271 @default.
- W2362034127 hasConceptScore W2362034127C153911025 @default.
- W2362034127 hasConceptScore W2362034127C190283241 @default.
- W2362034127 hasConceptScore W2362034127C204232928 @default.
- W2362034127 hasConceptScore W2362034127C2777546739 @default.
- W2362034127 hasConceptScore W2362034127C2993294228 @default.
- W2362034127 hasConceptScore W2362034127C34688535 @default.
- W2362034127 hasConceptScore W2362034127C502942594 @default.
- W2362034127 hasConceptScore W2362034127C526584372 @default.
- W2362034127 hasConceptScore W2362034127C553184892 @default.
- W2362034127 hasConceptScore W2362034127C55493867 @default.
- W2362034127 hasConceptScore W2362034127C71924100 @default.
- W2362034127 hasConceptScore W2362034127C86803240 @default.
- W2362034127 hasLocation W23620341271 @default.
- W2362034127 hasOpenAccess W2362034127 @default.
- W2362034127 hasPrimaryLocation W23620341271 @default.
- W2362034127 hasRelatedWork W1987546776 @default.
- W2362034127 hasRelatedWork W2019877419 @default.
- W2362034127 hasRelatedWork W2024741387 @default.
- W2362034127 hasRelatedWork W2044313321 @default.
- W2362034127 hasRelatedWork W2139878455 @default.
- W2362034127 hasRelatedWork W2230893852 @default.
- W2362034127 hasRelatedWork W2354086060 @default.
- W2362034127 hasRelatedWork W2357696120 @default.
- W2362034127 hasRelatedWork W2359606133 @default.
- W2362034127 hasRelatedWork W2375481860 @default.
- W2362034127 hasRelatedWork W2383685708 @default.
- W2362034127 hasRelatedWork W2384562646 @default.
- W2362034127 hasRelatedWork W2387220297 @default.
- W2362034127 hasRelatedWork W2387634853 @default.
- W2362034127 hasRelatedWork W2391351276 @default.
- W2362034127 hasRelatedWork W2392166498 @default.
- W2362034127 hasRelatedWork W2973022654 @default.
- W2362034127 hasRelatedWork W3028682169 @default.
- W2362034127 hasRelatedWork W3031166441 @default.
- W2362034127 hasRelatedWork W2605684978 @default.
- W2362034127 isParatext "false" @default.
- W2362034127 isRetracted "false" @default.
- W2362034127 magId "2362034127" @default.
- W2362034127 workType "article" @default.