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- W2362044028 abstract "Objective:To study the effects of Chan-Yu-Bao-Yuan-Tang on apoptosis of SK-MES-1 cell.Methods:The SK-MES-1 cells were incubated with different concentrations of Chan-Yu-Bao-Yuan-Tang(20、40、80、160μg/mL) for 48h and 72h.The morphologies of apoptotic were observed by fluorescence microscope.The Inhibitions rates of cell proliferation were detected by MTT.The apoptosis rates were detected by flow cytometry.The expression of caspase-3 activated fragments and gelsolin activated fragments were detected by western blot.Result:With the increasing of drug concentration and incubating time,it showed:The quantity of apoptosis cells increased under the fluorescence microscope;The Inhibitions rates of cell proliferation increased;The apoptosis rates of the early apoptotic cells and mid and late apoptotic or necrotic cells both increased;The expression of caspase-3 activated fragments and gelsolin activated fragments both increased.Conclusion:Chan-Yu-Bao-Yuan-Tang induces apoptosis of SK-MES-1 cell lines via a caspase-3-generated fragement of gelsolin pathway." @default.
- W2362044028 created "2016-06-24" @default.
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- W2362044028 date "2011-01-01" @default.
- W2362044028 modified "2023-09-26" @default.
- W2362044028 title "Research on Apoptosis and Mechanism of SK-MES-1 Cell Lines Induced by Chan-Yu-Bao-Yuan-Tang" @default.
- W2362044028 hasPublicationYear "2011" @default.
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